[Re]Re- and [Tc]Tc-Tricarbonyl Metal Complexes with 1,4,7-Triazacyclononane-Based Chelators Bearing Amide, Alcohol, or Ketone Pendent Groups.

1,4,7-Triazacyclononane (TACN)-based chelators, such as NOTA and NODAGA, have shown great promise as bifunctional chelators for [M(CO)] cores (M = Tc and Re) in radiopharmaceutical development. Previous investigations of TACN-based chelators bearing pendent acid and ester arms demonstrated the important role the pendent arms have in successful coordination of the [M(CO)] core with the TACN backbone nitrogens. In this work, we introduce three TACN-based bifunctional chelators bearing amide, alcohol, and ketone pendent arms and evaluate their (radio)labeling efficiency with the [M(CO)] core as well as the stability and hydrophilicity of the resulting radiometal complexes.

The effects of extended-wear hearing aids on the localization accuracy of listeners with normal audiometric thresholds.

Extended-wear hearing aids (EWHAs) are small broadband analog amplification devices placed deeply enough in the ear canal to preserve most of the cues in the head-related transfer function. However, little is known about how EWHAs affect localization accuracy for normal hearing threshold (NHT) listeners. In this study, eight NHT participants were fitted with EWHAs and localized broadband sounds of different durations (250 ms and 4 s) and stimulus intensities (40, 50, 60, 70, and 80 dBA) in a spherical speaker array.

Clinical outcomes of female external urine wicking devices as alternatives to indwelling catheters: a systematic review and meta-analysis.

Background: Female patients using indwelling urinary catheters (IUCs) are disproportionately at risk for developing catheter-associated urinary tract infections (CAUTIs) compared to males. Female external urine wicking devices (FEUWDs) have emerged as potential alternatives to IUCs for incontinence management.

Objectives: To assess the clinical risks and benefits of FEUWDs as alternatives to IUCs.

Distortion product otoacoustic mapping measured pre- and post-loud sound exposures.

Objective: Sampling distortion product otoacoustic emissions (DPOAEs) at multiple f/f ratios and f frequency values produces a DPOAE "map." This study examined the efficacy of DPOAE mapping compared with pure tone audiometry and standard DPOAEs for detecting noise effects in subjects exposed to loud sound.

Design: A map significance score was developed as a single measure of map change.

Attenuation characteristics of an extended-wear hearing aid: Impulse and continuous noise.

The extended-wear hearing aid (EWHA) is a hearing assistive device that combines a low-power analog amplification circuit with a soft biocompatible foam plug that allows it to remain in the ear canal for several months at a time without replacement. EWHAs fit snugly in the ear canal and are not vented and so produce insertion losses comparable to a passive earplug when inserted into the ear canal with the active circuitry turned off. However, EWHAs are not marketed as hearing protection devices, and other than a general warning to users that the device will have impaired auditory awareness when the device is inserted in the "off" mode, relatively little has been reported about the attenuation characteristics of EWHAs.