Publications by authors named "N D Nwankpa"
Rinderpest and peste des petits ruminants (PPR) are two closely related viral diseases caused by viruses belonging to the genus Morbillivirus and affecting ruminants. Both diseases are notifiable to the World Organisation for Animal Health (WOAH) due to their high contagiosity and economic importance. International collaboration and scientific developments have led to the eradication of rinderpest, which was celebrated in 2011, 250 years after the first veterinary school was created in Lyon.
View Article and Find Full Text PDFArticle Synopsis
- Peste des Petits Ruminants (PPR) is a disease common in Africa, and effective live attenuated vaccines (Nigeria 75/1 and Sungri/96 strains) are produced to combat it, but maintaining the cold chain for these vaccines is challenging.
- The study assessed the thermotolerance of various stabilizer formulations for freeze-dried and reconstituted PPR vaccines by testing their viability at different temperatures over time.
- Results indicated that the formulation with lactalbumin hydrolysate-sucrose showed the best stability, maintaining vaccine efficacy at higher temperatures, suggesting it should be the preferred stabilizer for vaccines distributed in warmer climates.
Peste des petits ruminants virus (PPRV), which is the only member of the species and belongs to the genus within the family, causes the highly contagious viral sickness "Peste des petits ruminants (PPR)." PPR is of serious economic significance for small ruminant production, particularly in Africa. Control of this critical disease depends highly on successful vaccination against the PPRV.
View Article and Find Full Text PDFContagious bovine pleuropneumonia (CBPP) is an infectious and contagious bacterial respiratory disease that affects cattle with significant economic losses to the African animal industry. The use of ELISA kits based on monoclonal antibodies (mAbs) will aid in quick and precise diagnosis of CBPP, contributing to disease control and prevention in cattle. Thus, this research aims to develop and evaluate monoclonal antibodies against CBPP (T1/44) antigen for use in ELISA kits for CBPP diagnosis.
View Article and Find Full Text PDFVaccination is the most cost-effective tool to control contagious bovine pleuropneumonia. The vaccines currently used in Africa are derived from a live strain called T1, which was attenuated by passage in embryonated eggs and broth culture. The number of passages is directly correlated to the degree of attenuation of the vaccinal strains and inversely correlated to their immunogenicity in cattle.
View Article and Find Full Text PDF