Publications by authors named "N D Nigro"
In vivo efficacy of uvangoletin from Piper aduncum (Piperaceae) against Schistosoma mansoni and in silico studies targeting SmNTPDases.
Exp Parasitol
January 2025
Schistosomiasis stands as one of the most significant parasitic diseases on a global scale, with approximately 250 million infections worldwide. It is imperative to address this pressing issue by developing new antischistosomal drugs. Chalcones have emerged as a promising class of natural compounds, demonstrating noteworthy effects observed in vitro experiments with Schistosoma mansoni, and demonstrating the ability to inhibit SmNTPDases and apyrase from potatoes.
View Article and Find Full Text PDFAssessment of change in end-tidal CO after fluid challenge as a marker of fluid responsiveness as measured by the aortic velocity time integral in healthy anesthetized mechanically ventilated dogs.
J Vet Emerg Crit Care (San Antonio)
December 2024
Objective: To evaluate if variation in the end-tidal CO partial pressure (∆Petco) after a fluid challenge could predict fluid responsiveness with a sensitivity of 75% and a specificity of 70% in healthy anesthetized and mechanically ventilated dogs.
Design: Diagnostic accuracy study.
Setting: University hospital.
Evaluation of cerebral autoregulation in dogs via transcranial color-coded duplex sonography and transient hyperemia testing.
J Vet Emerg Crit Care (San Antonio)
December 2024
Objective: To evaluate the changes in flow velocities of the middle cerebral artery before and after a carotid compression maneuver using transcranial color-coded duplex sonography (TCCD) in healthy anesthetized dogs under mechanical ventilation.
Design: Prospective study.
Setting: University teaching hospital.
Case report: granulomatous hepatitis due to Mycobacterium avium in an Atlantic yellow-nosed albatross (Thalassarche chlororhynchos) from Southern Brazilian coast.
Vet Res Commun
December 2024
Article Synopsis
- - The study details a case of granulomatous hepatitis in an Atlantic yellow-nosed albatross found dead in Brazil, caused by the bacteria Mycobacterium avium.
- - Necropsy revealed significant liver enlargement and granulomas with caseous necrosis, confirmed through bacterial culture and PCR analysis.
- - The findings highlight the need for wildlife surveillance in coastal areas, as pelagic birds can carry pathogens posing risks to other wildlife and domestic animals.
Objective: To compare static compliance of the respiratory system (C) and the ratio of partial pressure of end-tidal to arterial carbon dioxide (Pe'CO/PaCO), in healthy dogs using two approaches for tidal volume (V) selection during volume-controlled ventilation: body mass based and driving pressure (ΔPaw) guided.
Study Design: Randomized, nonblinded, crossover, clinical trial.
Animals: A total of 19 client-owned dogs anesthetized for castration and ovariohysterectomy.