[EFFECT OF PROPRANOLOL ON CYTOKINE PROFILE IN AN EXPERIMENTAL MODEL OF HUMAN T LYMPHOCYTES (JURKAT CELLS) IN VITRO].

In this research, in order to establish the role of neuroendocrine mechanisms in the processes of immunomodulation, the effect of propranolol on the cytokine profile in an experimental model of human T lymphocytes (Jurkat cells) in vitro was investigated. Jurkat cells were incubated under standard conditions. Stimulation of the Jurkat cells was performed by incubation with Phytohemagglutinin (PHA) (50 μg/ml) in the presence of propanonol (10-4 M) and without it at 370 for 24 hours.

[THE BIOMARKERS OF MYOCARDIAL DAMAGE AND THEIR ROLE IN THE PROGRESSION OF HEART FAILURE (REVIEW)].

Despite the success achieved in the study and treatment of chronic heart failure, this syndrome still remains one of the most difficult and predictable unreliable pathologies. Moreover, in recent years there has been a tendency of growth of such patients. Based on the above, the attention of scientists focuses on new concepts that involve the study of new biomarkers of cardiac damage and the definition of their role in the progression of heart failure.

[Metabolic issues of ischemia induced myocardial dysfunction].

Myocardial ischemia represents most common cause of necrosis of cardiomyocytes, cardio sclerosis and heart failure. Main clinical manifestation of myocardial ischemia is systolic and/or diastolic dysfunction. It has been shown, that local disturbance of myocardial contractility is not always determined by cell necrosis and cardio sclerosis, as improvement of coronary perfusion may lead to restoration of contractile function of myocardium.

Role of oxidative stress in pathogenesis of atherosclerosis.

Atherosclerotic disease remains a major cause of death. Documented cases of atherosclerosis in Georgia (Caucasus) have increased by up to 40% and, moreover, the disease is occurring with increased frequency and greater severity in younger adults. Prevention of atherosclerosis as well as detection at early stages of the disease is reviewed.

[Role of immune inflammatory activity in chronic heart failure progress].

Significant role of immune inflammatory reactions along with activation of the RAAS (rennin-angiotensin-aldosterone system) and the sympatho-adrenal system in CHF (chronic heart failure) pathogenesis is considered in the present survey article. Together with haemodynamic disorders activation of inflammatory reactions, which involve anti-inflammatory cytokines, is shown to be one of the main factors affecting CHF course and prognosis. Alteration of cytokine level is associated with injury level, gravity of the disease course and its clinical outcome.