Publications by authors named "N D Maharani"
This research describes the synthesis and characterization of a molecularly imprinted polymer (MIP) as a candidate for the transdermal delivery of curcumin. The MIP was synthesized through precipitation polymerization using methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross-linking agent. MIP characterization studies were conducted using SEM-EDX and FTIR spectroscopy to determine the morphology and interaction between curcumin and polymers.
View Article and Find Full Text PDFSafety and immunogenicity of a SARS-CoV-2 recombinant protein subunit vaccine adjuvanted with Alum + CpG 1018 in healthy Indonesian adults: A multicenter, randomized, comparative, observer-blind, placebo-controlled phase 2 study.
Hum Vaccin Immunother
December 2024
Globally, dozens of COVID-19 vaccines are licensed under emergency or conditional authorization, but especially in low and middle-income countries, their availability varies. Indonesia decided to become independent and produce its own vaccines locally. This study investigated the safety and immunogenicity of a SARS-CoV-2 recombinant protein subunit vaccine adjuvanted with Alum + CpG 1018.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on the environmental factors affecting leptospirosis cases in Klaten Regency, Central Java, Indonesia, analyzing data from 2018 to describe both abiotic and biotic influences.
- - Key abiotic factors linked to higher leptospirosis incidence included poor waste disposal, bad gutter conditions, close rivers, and a history of flooding, while the biotic factors showed that all cases were associated with rat nests, along with some homes having pets and multiple vegetation types.
- - The findings suggest a strong need for rat control programs and public education to improve environmental cleanliness, highlighting the importance of collaboration between sectors like agriculture and health to combat leptospirosis outbreaks.
Early identification and treatment of genetic and neurodevelopmental disorders.
J Intellect Disabil Res
September 2024
Background: The combined effects of metformin and epigallocatechin-3-gallate (EGCG) on cortisol, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), and blood glucose levels have not been investigated. This study evaluated the effectiveness of combining EGCG with metformin in regulating those levels in a rat model of diet-induced diabetes and obesity.
Methods: Thirty diabetic and obese rats on a high-fat diet were treated daily for 28 days with EGCG (100 mg/kg of body weight/day), metformin (200 mg/kg of body weight/day), or both.