Publications by authors named "N D Linhares"
To investigate de effect of PAb gel on the bone tissue of rats submitted to Bisphosphonate-related osteonecrosis of the jaws (BRONJ). Initially, 54 animals were submitted to BRONJ model by Zoledronic Acid (ZA) (0.1 mg/kg 3x/wk for 9 wk, ip), followed by the 1st upper left molar extraction at the 8th wk.
View Article and Find Full Text PDFSocial, Genetics and Histopathological Factors Related to () Gene Mutation and Survival in Women with Ovarian Serous Cystadenocarcinoma: Bioinformatics Analysis.
Genes (Basel)
May 2023
Article Synopsis
- The study explored factors that may heighten the risk of ovarian serous cystadenocarcinoma, focusing on the connection between social, genetic, and histopathological elements in women with titin mutations.
- Researchers analyzed data from 585 patient samples to determine if the mutation in the titin gene could serve as a predictor of outcomes, using statistical methods such as logistic regression and Kaplan-Meier survival analysis.
- Findings revealed that titin mutations did not vary by age, tumor stage, or race but were linked to several genetic markers and metrics related to cancer cell metabolism, revealing a significant impact on mutation frequency and survival indicators.
The Impact of Training Time on Understanding the Treatment of Adolescent Idiopathic Scoliosis According to SOSORT International Guidelines: An Online Survey Study.
Children (Basel)
October 2022
The lack of knowledge by health professionals in the management of scoliosis can lead to an erroneous diagnosis. The aim of the current study was to understand the influence of length of professional experience on the knowledge of Brazilian physical therapists regarding international guidelines for the treatment of adolescent idiopathic scoliosis. The study was conducted using an online questionnaire consisting of 23 questions, divided into 8 questions on sociodemographic data and 15 questions based on information provided by the guidelines in the SOSORT 2016.
View Article and Find Full Text PDFBackground And Objectives: encodes the voltage-gated potassium channel EAG2/Kv10.2. We aimed to delineate the neurodevelopmental and epilepsy phenotypic spectrum associated with de novo variants.
View Article and Find Full Text PDFA uniparental disomy (UPD) screen using whole genome sequencing (WGS) data from 164 trios with rare disorders in the Irish population was performed to identify large runs of homozygosity of uniparental origin that may harbour deleterious recessive variants. Three instances of whole chromosome uniparental isodisomy (UPiD) were identified: one case of maternal isodisomy of chromosome 1 and two cases of paternal isodisomy of chromosome 2. We identified deleterious homozygous variants on isodisomic chromosomes in two probands: a novel p (Glu59ValfsTer20) variant in , and a p (Pro222Leu) variant in , respectively.
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