Publications by authors named "N D Leigh"
Background: Comparisons of nicotine and toxicant exposure between people who use different alternative tobacco products remains underexplored.
Methods: This cross-sectional, multi-country study analyzed urinary metabolites of nicotine, NNK, and volatile organic compounds (acrolein, acrylamide, acrylonitrile) among established users (n=550) in Japan and Canada. Participants exclusively or concurrently used nicotine vaping products (NVPs; Canada only), heated tobacco products (HTPs; Japan only), and combustible cigarettes (CCs; Japan and Canada), or abstained (Japan and Canada).
Article Synopsis
- As of 2023, Elfbar is the leading brand of disposable e-cigarettes in the US and UK, with variations in nicotine levels: 5% in the US and 2% in the UK.
- A study tested eight Elfbar devices from both countries, measuring nicotine concentration, aerosol emissions, and flavoring chemicals, finding significant differences in these aspects.
- US Elfbars contained significantly higher nicotine volumes and concentrations, delivering four times more nicotine per puff than UK versions, along with varying types of flavoring chemicals.
Rationale: While tobacco industry data suggests that switching from combustible cigarettes to heated tobacco products (HTPs), like IQOS, may reduce the users' exposure to respiratory toxicants, it is not known if using HTPs impacts the outcomes of acute respiratory infections.
Objectives: Does switching from cigarettes to HTPs improve responses to pulmonary infection.
Methods: We conducted experiments in which 3 groups of mice were pre-exposed to cigarette smoke for 8 weeks, followed by 8-week exposure to (1) HTPs (tobacco product switching), (2) air (smoking cessation), or (3) continued exposure to cigarette smoke.
The goal of this article is to give an overview of intraoperative liver ultrasound, including the indications, different ultrasound techniques, and the ultrasound appearance of normal anatomy, more common anatomic variations, and common hepatic tumors.
View Article and Find Full Text PDFCellular senescence is a state in which cells enter cell cycle arrest. However, senescent cells have the ability to secrete signaling molecules such as chemokines, cytokines, and growth factors. This secretory activity is an important feature of senescent cells, since the secreted factors impact the surrounding cellular microenvironment.
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