[Transplacental transmission of the causative agent in experimental rickettsial infection].

It was shown in the experiments on the model of typhus infection in guinea-pigs that the pathogenic organism can be inherited by foetus from the mother's organism in the period of acute infection. It is confirmed by the presence of positive seroconversion in 86% of born offsprings and the character of the immunity response after the control infection that is the initial formation of immunoglobulins of form G (Ig G). At the same time there was no such a transfer of pathogenic organisms in 14% of offsprings.

[Q fever in the western region of Ukraine].

Multiple natural and mixed foci of Q fever have been revealed at the territory of six administrative regions of the western part of the Ukraine. Coxiella burnetii strains have been isolated from small animals and ticks, the specific features of their ecology in Poles'e and forest-steppe zones have been determined. The necessity of the study of natural foci of Q fever at not yet surveyed territories for at least 3-4 years has been substantiated.

[Chemotherapeutic effectiveness of doxycycline in experimental Q fever].

Comparative chemotherapeutic efficacy of doxycycline administered orally or parenterally was studied on a model of experimental Q fever in guinea pigs and albino mice. The advantage of the parenteral use of the antibiotic was observed only in the treatment of the albino mice. Optimization of the doses and time of doxycycline use providing the maximum therapeutic effect and the required levels of the complement binding antibodies was achieved with employing the multifactorial analysis.

[Optimal combined use of rifampicin and immunomodulator of microbial origin in experimental Q-Rickettsia infection].

Multifactorial analysis of the combined use of rifampicin and an immunomodulator of the microbial origin, such as peptidoglycan, was performed on a model of experimental Q fever in albino mice. On the basis of the experimental results, statistic polynomial models describing the weight of the murine spleens and the titers of the complement-binding antibodies were designed. It was shown that the action of the immunomodulator and antibiotic was highly synergistic with respect to the chemotherapeutic activity and antibody titers.