HPLC determination of majdine in Vinca herbacea.

A reliable HPLC method coupled with DAD detection was developed and validated for determination of majdine in Vinca herbacea. The chromatographic separation was carried out on a Symmetry C18 column (250 mm x 4.6 mm, 5 microm, Waters) with an isocratic solvent system of 25 mM potassium phosphate buffer (pH = 3.

Development of solid, dosage forms of medicinal drugs from indoline group alkaloids.

According to biopharmaceutical investigations, the regimen of the tablets of alkaloid containing new galenic preparation of indoline and indole group - Vinkabral, Vingerbin has been developed. Also, the preparation technology was worked out and it has been defined that optimal method of tabletting new galenic formulations, such as Vincabral and Vingerbin is direct pressing by using polifunctional additional formulations - Proslov SMCC (siliced methylceluslose) and Glikonat Sodium of Starch. Their influence on the technological characteristics are studied, so as the proportion of additional compounds are defined.

Apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kit.

In the present study, apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and Kit were studied. For testing the possible apoptotic effects of majdine and isomajdine from V.

[Extraction of pharmacologically active alkaloids from Vinca species].

From the Genius Vinca the drugs have been received, arbitrally named: Vingerbin- with anthyarithmic activity, Vincabral-for improvement of brain blood circulation and leicobetin-as stimulator of leicopoesis. The investigations has been performed for creation of rational, resource saving, rentable phyto technologies. As a result, the liquid extraction general schema is provided for receipt of indolic alkaloids from plants V.