Publications by authors named "N D Berkman"
Background: Fibroblast differentiation to a myofibroblast phenotype is a feature of airway remodeling in asthma. Lung fibroblasts express the integrin receptor αβ and fibronectin induces myofibroblast differentiation via this receptor.
Objectives: To investigate the role of the β7 integrin receptor subunit and αβ integrin complex in airway remodeling and airway hyperresponsiveness (AHR) in a murine model of chronic allergen exposure.
Chronic cough (CC) is a prevalent yet underexplored medical condition, with limited real-world data regarding its healthcare burden. This study investigates the epidemiology, associated comorbidities, and healthcare service utilization among patients with CC. In this retrospective cohort study, adult patients with at least 3 physician diagnoses of cough over a period spanning a minimum of 8 weeks and a maximum of 12 months anytime between 2009 and 2018, were defined as patients with CC (PwCC).
View Article and Find Full Text PDFBackground: Workup of bronchiectasis patients mandates microbiological characterization often being sought via Bronchoscopy. However, whether to perform bronchial or lung biopsies, is unknown, especially for the diagnosis of NTM pulmonary disease. We aimed to assess the current practice and yield of the different bronchoscopic procedures in this setting.
View Article and Find Full Text PDFArticle Synopsis
- Observational epidemiologic studies are important for understanding how environmental, occupational, and behavioral factors impact human health, and systematic reviews help guide policies based on these studies.
- A new assessment tool called Risk Of Bias In Non-randomized Studies - of Exposures (ROBINS-E) has been created to evaluate the risk of bias in cohort studies examining the effects of specific exposures on outcomes.
- ROBINS-E offers a structured method to assess bias through multiple domains using signaling questions, and aims to improve how biases are integrated into evidence synthesis and causal inference in research.
Importance: Telemedicine use was common during the COVID-19 pandemic, expanding many patients' approaches to accessing health care. Of concern is whether telemedicine access was poorer among higher-needs and disadvantaged populations.
Objective: To assess patient characteristics associated with telemedicine use and telemedicine mode and describe telemedicine visit experiences by telemedicine mode.