Publications by authors named "N D'Alessandris"
Micropapillary pattern in serous borderline ovarian tumor and the risk of extraovarian localization of low-grade serous carcinoma ('invasive implants'): A systematic review and meta-analysis.
Pathol Res Pract
December 2024
In serous borderline ovarian tumor (SBOT), a micropapillary (MP) pattern has been considered analogous to intraepithelial low-grade serous carcinoma (LGSC). On this account, it is reasonable to hypothesize that MP-SBOT is more likely to be associated with extraovarian LGSC localizations (also referred to as 'invasive implants') compared to conventional SBOT. The aim of this study was to investigate the potential association between a MP pattern and invasive implants in SBOT.
View Article and Find Full Text PDFEndometrial carcinoma is a heterogeneous group of malignancies characterized by distinct histopathological features and genetic underpinnings. The 2020 WHO classification has provided a comprehensive framework for the categorization of endometrial carcinoma. However, it has not fully addressed the spectrum of uncommon entities that are currently not recognized by the 2020 WHO and have only been described in the form of small case series and case reports.
View Article and Find Full Text PDFPrognostic value of electroanatomic-guided endomyocardial biopsy in patients with myocarditis, arrhythmogenic cardiomyopathy and non dilated left ventricular cardiomyopathy.
Int J Cardiol
December 2024
Article Synopsis
- The study investigates various techniques for assessing Sudden Cardiac Death (SCD) risk in patients with non-ischemic cardiomyopathy (NICM), focusing on non-invasive and invasive methods like imaging and electrophysiological studies.
- The goal is to evaluate how three-dimensional electroanatomic mapping (3D-EAM), combined with other diagnostics like genetic screening and endomyocardial biopsy, can enhance early diagnosis and prognosis in patients with unexplained complex ventricular arrhythmias (VAs).
- Results indicate that factors such as the presence of sustained ventricular tachycardia, the total bipolar scar area in the ventricles, and a histological diagnosis of myocarditis are significant predictors of complex VAs or
Article Synopsis
- * Out of 244 patients reviewed, 36 (14.7%) exhibited post-radiotherapy serous-like endometrial changes (PoRSEC), showing similarities in nuclear atypia with SEIC but differing in specific features like papillary architecture and mitotic activity.
- * Immunohistochemical findings revealed that while SEIC consistently showed aberrant p53 expression and high Ki67 levels, PoRSEC was more variable and included some p53 positivity, making differential diagnosis challenging but with distinct patterns between the two.
Article Synopsis
- Primary neuroendocrine neoplasms (NENs) of the breast are identified by specific neuroendocrine features and must be confirmed with positive immunohistochemical markers like Chromogranin and Synaptophysin.
- * Diagnose breast NENs requires excluding the possibility of similar tumors originating from other body sites.
- * The 2022 WHO classification has categorized breast NENs into well-differentiated neuroendocrine tumors (NETs) and aggressive neuroendocrine carcinomas (NECs), distinguishing them from typical invasive breast cancers.