Publications by authors named "N Crevier-Denoix"

The measurement of musculoskeletal tissue properties and loading patterns during physical activity is important for understanding the adaptation mechanisms of tissues such as bone, tendon, and muscle tissues, particularly with injury and repair. Although the properties and loading of these connective tissues have been quantified using direct measurement techniques, these methods are highly invasive and often prevent or interfere with normal activity patterns. Indirect biomechanical methods, such as estimates based on electromyography, ultrasound, and inverse dynamics, are used more widely but are known to yield different parameter values than direct measurements.

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Article Synopsis
  • Researchers analyzed the anatomy of 2,089 jumping horses using 3D video to identify 43 anatomical landmarks and defined new phenotypes that captured the horses' shapes, which were then utilized in genetic studies.
  • They discovered ten distinct shapes accounting for 86% of anatomical variance, with varying heritabilities, and identified a weak genetic link between one shape and competition success.
  • The findings suggest that breeding goals set by judges may focus on improving certain anatomical features that negatively correlate with each other, highlighting complex relationships in horse morphology and genetics despite SNPs associated with height not directly correlating to specific shapes.
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A randomized controlled trial was performed on racing horses, to evaluate the efficacy of a new class of therapeutic agents in regenerative medicine-ReGeneraTing Agents® (RGTA®), to treat tendinopathies. Preliminary uncontrolled studies on tendon healing in racing horses with RGTA® (OTR4131)-Equitend® showed encouraging results, justifying performing a randomized, controlled, multicenter study with a two-year racing performance follow up. The objective of this study was to evaluate the effect of Equitend® versus placebo on acute superficial digital flexor tendonitis in racing French Standardbred Trotters (ST).

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