Publications by authors named "N Cote"
Clinical Outcomes, Patterns of Failure, and Salvage Therapies of a Large Modern Cohort of Patients With Anal Squamous Cell Carcinoma Treated With Definitive-Intent Intensity-Modulated Radiation Therapy.
Int J Radiat Oncol Biol Phys
November 2024
Purpose: Patterns of failure and salvage therapy options for patients with anal squamous cell carcinoma (ASCC) who recur after definitive-intent intensity-modulated radiation therapy (IMRT) with concurrent chemotherapy are not well described.
Methods And Materials: We identified consecutive patients with ASCC treated with definitive-intent IMRT between July 2005 and December 2019. Relevant patient and tumor parameters, disease outcomes (locoregional failure [LRF], distant failure, progression-free survival, colostomy-free survival, and overall survival [OS]), patterns of failure, and salvage therapies were collected.
Article Synopsis
- Bicuspid aortic valve (BAV) shows increased progression of aorta dilation compared to tricuspid aortic valve (TAV) in patients with aortic stenosis, with a median annualized change of 0.33 mm/year for BAV versus 0.21 mm/year for TAV.
- Factors influencing the dilation rate differ by valve type; BAV patients are more affected by low-density lipoprotein (LDL) levels, while TAV patients are influenced by the apolipoprotein B/A-I ratio and baseline aortic jet velocity.
- The study highlights that men and women have different predictors for AA dilation; men’s dilation relates to baseline jet velocity and aortic diameter, while
Article Synopsis
- Aortic valve stenosis (AS) is a chronic disease that progresses at different rates among patients, making it challenging to predict its progression.* -
- This study utilized machine and deep learning algorithms on data from 303 patients to forecast AS progression over the next 2 and 5 years, showing that the LightGBM model yielded the best predictive performance.* -
- The findings suggest that using AI in clinical settings can improve the risk assessment of AS, effectively predicting the disease progression and outcomes for patients with mild-to-moderate AS.*
Background: Little is known about the effect of sex on functional status decline in aortic valve stenosis (AS) patients.
Objectives: The purpose of this study was to examine the changes in functional status according to sex in patients with mild-to-moderate AS and its association with the composite of death or aortic valve replacement (AVR).
Methods: We included patients with mild-to-moderate AS prospectively recruited in the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study (NCT01679431).
Background: Aortic stiffness is measured by carotid-femoral pulse wave velocity (PWV), but it can also be estimated (ePWV) based on age and brachial mean arterial pressure (MAP). However, diabetes mellitus and/or chronic kidney disease (DM/CKD) may cause more pronounced damage to the arterial wall, changing the pressure and PWV relationship. Furthermore, sex and height could affect PWV through their relationship to the arterial diameter and path length.
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