Publications by authors named "N Collercandy"
Background: The persistence of latently infected cells prevents a cure of HIV. The intestinal mucosa contains numerous target cells, and high levels of HIV-1 DNA persist in this compartment under ART. While CD4+ T cells are the best characterized reservoir of HIV-1, the role of long-lived intestinal macrophages in HIV-1 persistence on ART remains controversial.
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- This study investigates the role of the gut as a reservoir for intact HIV-1 proviruses, which contribute to viral rebound in patients on antiretroviral therapy.
- Blood samples and intestinal biopsies from 42 HIV-1 positive individuals revealed that intact proviruses are notably concentrated in the colon, and their presence is linked to ongoing immune activation.
- The research suggests that the gut's HIV-1 reservoir is influenced by the proliferation of specific T cells, highlighting the gut's significance in maintaining viral persistence despite treatment.
Article Synopsis
- This study looked at why some people sweat a lot and found that many have underlying diseases like cancers or infections.
- Out of 420 patients studied, about 17% didn't get a specific diagnosis for their sweating.
- Doctors discovered that certain signs, like fever and how long the sweating lasts, can help them figure out if the sweating is linked to something serious or not.