Publications by authors named "N Christodoulou"

Disasters, both natural and man-made, impose a significant burden on the mental health of individuals, communities, and societies. The frequency and intensity of disasters is increasing; 3-4 fold compared to the last century, with 400-500 significant disasters/year, affecting >1.5 billion people worldwide and costing 250-400 billion dollars/year.

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Background: Recent evidence brings autophagy, and specifically the RB1CC1 gene into sharp focus as aetiologically relevant to Schizophrenia. Our understanding of whether and how these genetic signatures translate to cellular functions remains limited.

Material And Methods: Post-mortem study of 10 individuals with Schizophrenia and 18 individuals without any neurological/psychiatric disorder, matched for age, sex, post-mortem-interval, pH and BRAAK score.

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Unlabelled: To the Editors, We recently published evidence-based guidelines for the role of exercise in the prevention of dementia.1 The guidelines combined an umbrella review and expert consensus, and has important implications for psychiatry. Evidence from published studies was evaluated using the GRADE assessment.

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Background: Capsular contracture after implant-based breast reconstruction is not an uncommon problem and affects reconstruction outcomes. It can be influenced by various factors, such as the plane of implant placement, implant surface and implant type. This systematic review and meta-analysis aimed to evaluate how the abovementioned risk factors can affect capsular contracture rates.

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Article Synopsis
  • Researchers aimed to understand the heterogeneity of pancreatic ductal adenocarcinoma by focusing on epigenetically regulated pathways that affect its progression.
  • They discovered that hypermethylation of the Hepatocyte Nuclear Factor 4A (HNF4A) gene leads to its suppression, which is linked to the growth and severity of pancreatic cancer.
  • The study concludes that loss of HNF4A due to DNA methylation contributes to the disease's development and is associated with worse survival outcomes for patients.
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