Publications by authors named "N Chow"
The Canadian Stroke Best Practice Recommendations (CSPR) 7th edition includes this new module on the diagnosis and management of vascular cognitive impairment (VCI) with or without neurodegenerative disease. An expert writing group and people with VCI lived experience (PWLE) reviewed current evidence. Existing recommendations were reviewed and revised, and new recommendations added.
View Article and Find Full Text PDFNuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights.
Cytokine Growth Factor Rev
January 2025
Receptor tyrosine kinases (RTKs) are membrane sensors that monitor alterations in the extracellular milieu and translate this information into appropriate cellular responses. Epidermal growth factor receptor (EGFR) is the most well-known model in which gene expression is upregulated by mitogenic signals through the activation of multiple signaling cascades or by nuclear translocation of the full-length EGFR protein. RON (Receptuer d'Origine Nantatise, also known as macrophage stimulating 1 receptor, MST1R) has recently gained attention as a therapeutic target for human cancer.
View Article and Find Full Text PDFBiological systems are complex, encompassing intertwined spatial, molecular and functional features. However, methodological constraints limit the completeness of information that can be extracted. Here, we report the development of INSIHGT, a non-destructive, accessible three-dimensional (3D) spatial biology method utilizing superchaotropes and host-guest chemistry to achieve homogeneous, deep penetration of macromolecular probes up to centimeter scales, providing reliable semi-quantitative signals throughout the tissue volume.
View Article and Find Full Text PDFArticle Synopsis
- Amplification of the HER2 receptor and overexpression of estrogen and progesterone receptors are crucial for planning breast cancer treatments, but resistance to drugs is common, highlighting the need for new advances.
- This study is the first to reveal that EMP3, a membrane protein, interacts with HER2 in breast cancer, promoting cell growth, invasion, and migration while increasing estrogen and progesterone receptor levels.
- Knocking down EMP3 reduced breast cancer cell growth and increased sensitivity to the drug trastuzumab, suggesting that targeting EMP3 could be a promising new treatment strategy for patients, especially in those with co-expression of EMP3 and HER2.
Article Synopsis
- - The study investigates cardiac allograft vasculopathy (CAV), a major cause of failure and death post-heart transplant, using single-cell RNA-sequencing to identify potential new biomarkers and pathways for early diagnosis and treatment.
- - Researchers collected blood from 22 heart transplant recipients with CAV and 18 without, analyzing over 134,000 cells and finding notable increases in specific immune cells associated with high-grade CAV, alongside 745 differentially expressed genes linked to inflammation and blood vessel growth.
- - The findings suggest that measuring specific gene expression in the blood could help diagnose CAV, and that targeting identified pathways might lead to new treatments to prevent its progression.