Publications by authors named "N Cheikh"
Refractory chronic immune thrombocytopenia (r-cITP) is one of the most challenging situations in chronic immune thrombocytopenia (cITP). Pediatric r-cITP is inconsistently defined in literature, contributing to the scarcity of data. Moreover, no evidence is available to guide the choice of treatment.
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- * Inherited mutations affecting T cell immunity, particularly biallelic variants in IL27RA, can result in severe primary EBV infections, with one allele more common in the Finnish population linked to increased risk of severe IM.
- * IL-27 and its receptor IL-27RA play a significant role in T cell response to EBV; deficiencies in IL-27RA lead to impaired T cell growth against the virus, yet these same deficiencies could explain why some patients recover well despite severe initial infections.
Introduction: Globally, resources for health spending, including HIV and tuberculosis (TB), are constrained, and a substantial gap exists between spending and estimated needs. Optima is an allocative efficiency modelling tool that has been used since 2010 in over 50 settings to generate evidence for country-level HIV and TB resource allocation decisions. This evaluation assessed the utilisation of modelling to inform financing priorities from the perspective of country stakeholders and their international partners.
View Article and Find Full Text PDFAutoimmune cytopenia (AIC) in children may be associated with positive antinuclear antibodies (ANA) and may progress to systemic lupus erythematosus (SLE). We evaluated the risk of progression to SLE of childhood-onset ANA-associated AIC. In the French national prospective OBS'CEREVANCE cohort, the long-term outcome of children with ANA-associated AIC (ANA titer ≥1/160) and a subgroup of children who developed SLE were described.
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