Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers.

Synthetic lethality in homologous recombination (HR)-deficient cancers caused by Poly (ADP-ribose) polymerase inhibitors (PARPi) has been classically attributed to its role in DNA repair. The mode of action of PARPi and resistance thereof are now believed to be predominantly replication associated. Therefore, effective combinatorial approaches of targeting replication fork processing along with HR-downregulation to target HR-proficient and possibly PARPi-resistant tumors are warranted.

The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of .

Unlabelled: has emerged as a multidrug-resistant human fungal pathogen that causes infections of high morbidity and mortality. However, the molecular mechanisms underlying pronounced multidrug resistance and host-pathogen interactions are poorly understood. Here, we show that lysine acetyltransferase is essential for cell wall remodeling, antifungal drug resistance, and virulence.

Evaluation of the techno-functional properties of lactobacilli strains originated from Bos indicus and Bubalus bubalis calves for probiotic potential.

The current study was undertaken to isolate, characterize, and cluster lactobacilli strains of indigenous cattle (Bos indicus) and buffalo (Bubalus bubalis) calf origin to develop a species-specific multistrain potential probiotic adjunct. Bacterial strains were isolated from the feces of Bos indicus and Bubalus bubalis calves of different breeds, i.e.