Publications by authors named "N Charasz"
Background And Objectives: Elderly subjects are still poorly represented in clinical trials, because of unjustified upper age limits. The prejudged reluctance of elderly patients to participate in trials could also be a barrier to their inclusion. The objective of this pilot study was to clarify the position of elderly subjects on their motivations and the reasons for their ultimate refusal to participate in clinical trials.
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- The study examined 35 patients with fundic atrophic gastritis and achlorhydria, classifying them into two groups based on the presence of hyperplasia of enterochromaffin-like cells.
- It found that patients with the hyperplastic group had significantly higher levels of circulating gastrin and increased antral G-cell hyperplasia compared to those without hyperplasia.
- Additionally, only the hyperplastic group showed increased histamine content and histidine decarboxylase activity in fundic biopsies, linking argyrophil-cell hyperplasia to elevated gastrin levels rather than the severity of gastritis.
[Isolation of a Campylobacter jejuni-like bacteria from gastric mucosa].
Gastroenterol Clin Biol
March 1989