Publications by authors named "N Chapelle"
Gastric cancer (GC) is still one of the most prevalent cancers worldwide, with a high mortality rate, despite improvements in diagnostic and therapeutic strategies. To diminish the GC burden, a modification of the current diagnostic paradigm, and especially endoscopic diagnosis of symptomatic individuals, is necessary. In this review article, we present a broad review and the current knowledge status on serum biomarkers, including pepsinogens, gastrin, Gastropanel, autoantibodies, and novel biomarkers, allowing us to estimate the risk of gastric precancerous conditions (GPC)-atrophic gastritis and gastric intestinal metaplasia.
View Article and Find Full Text PDFBoth sugars and lipids are important biomolecular building blocks with exceptional conformational flexibility and adaptability to their environment. Glycolipids bring together these two molecular components in the same assembly and combine the complexity of their conformational landscapes. In the present study, we have used selective double resonance vibrational spectroscopy, in combination with a computational approach, to explore the conformational preferences of two glycolipid models (3-0-acyl catechol and guaiacol α-D-glucopyranosides), either fully isolated in the gas phase or controlled interaction with a single water molecule.
View Article and Find Full Text PDFArticle Synopsis
- Patients with autoimmune gastritis (AIG) show higher rates of iron and vitamin B12 deficiencies compared to those with non-autoimmune gastritis (NAIG) and control groups.
- Median vitamin B12 levels are significantly lower in AIG patients (367.5 pg/mL) than in NAIG (445.0 pg/mL) and controls (391.0 pg/mL), with deficiencies found in 13.3% of AIG cases versus only 1.5% and 2.8% in the other groups.
- The study emphasizes the importance of screening and treating these micronutrient deficiencies in AIG patients, as they are at a higher risk for both vitamin B12 (OR:
Gastric mucosa-associated lymphoid tissue (MALT) lymphomas (GML) are non-Hodgkin lymphomas arising from the marginal zone of the lymphoid tissue of the stomach. They are usually induced by chronic infection with ; however, -negative GML is of increasing incidence. The diagnosis of GML is based on histological examination of gastric biopsies, but the role of upper endoscopy is crucial since it is the first step in the diagnostic process and, with currently available novel endoscopic techniques, may even allow an in vivo diagnosis of GML per se.
View Article and Find Full Text PDFArticle Synopsis
- Recent increases in gastric cancer incidence, especially among young women, are puzzling, with autoimmunity possibly playing a role in this new type of cancer.
- In a study with 355 patients, researchers examined the prevalence of 19 autoantibodies in those with chronic atrophic gastritis (CAG) and found that anti-nuclear antibodies (ANA) were more common in autoimmune gastritis (AIG) patients compared to others.
- While ANA positivity was linked to being female, overall findings indicated that common autoantibodies were not significantly more prevalent in CAG patients, suggesting that routine autoantibody testing may hold limited clinical relevance in these cases.