Publications by authors named "N Chandrasekharan"
Article Synopsis
- * The study involved 90 patients suspected of having PWS or AS, where DNA was extracted and analyzed using different methods to determine the cost-effectiveness and reliability of the tests.
- * Results showed a positive identification of PWS in 19 out of 37 cases and AS in 5 out of 53, indicating the kit-based testing method was more reliable and could improve patient care by facilitating affordable access to accurate diagnosis and therapy.
Article Synopsis
- Cutaneous leishmaniasis in Sri Lanka is unusual, as it is typically caused by Leishmania donovani, which is mainly associated with visceral disease.
- Genome analysis of clinical isolates from Sri Lanka revealed that both L. donovani and L. tropica are present, with some L. tropica strains linked to older Indian isolates rather than recent hybrids.
- The findings suggest that L. donovani is not the sole cause of cutaneous leishmaniasis in Sri Lanka, pointing to potential interspecies hybrids contributing to the disease.
High-resolution melt (HRM) analysis is a closed-tube technique for detecting single nucleotide polymorphisms (SNPs). However, it has limited use in high-resolution melting devices, even those with high thermal accuracy (HTA). In addition to the cost of switching to these specialized devices, the presence of nearest neighbour neutral changes (class III, IV SNPs and small indels) made HRM-based assays a challenging task due to reduced sensitivity.
View Article and Find Full Text PDFBackground: Williams Beuren Syndrome (WBS) is a well-recognized and common genetic cause of congenital heart defects, developmental delay, hypercalcemia, and characteristic facial features. It is caused by a 1.5 - 1.
View Article and Find Full Text PDFFungal Cell Wall-Associated Effectors: Sensing, Integration, Suppression, and Protection.
Mol Plant Microbe Interact
March 2024
The cell wall (CW) of plant-interacting fungi, as the direct interface with host plants, plays a crucial role in fungal development. A number of secreted proteins are directly associated with the fungal CW, either through covalent or non-covalent interactions, and serve a range of important functions. In the context of plant-fungal interactions many are important for fungal development in the host environment and may therefore be considered fungal CW-associated effectors (CWAEs).
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