Publications by authors named "N Ch Srinivas"
Bexicaserin is a highly selective agonist at the 5-HT receptor in clinical development for the treatment of seizures associated with developmental and epileptic encephalopathies (DEEs). We report an LC-MS/MS method for the quantitative estimation of bexicaserin in human plasma and urine. The sample preparation involves the extraction of bexicaserin and internal standard (CD-bexicaserin; IS) from 150 μL plasma and 50 μL urine using a solid phase extraction method.
View Article and Find Full Text PDFObjective: Family-centered rounds (FCR) is the standard for pediatric communication, but community pediatric hospital medicine services may face barriers in implementation, including offering FCR to families with a language preference other than English (LOE) versus those with an English preference (EP). The goal of our quality improvement project was to increase FCR from 33% to 80% over 1 year.
Methods: Interventions included an FCR checklist integrated into the electronic healthcare record (EHR-FCR checklist), staff education, visual prompts, and interpreters.
Article Synopsis
- The study investigates the effects of primary tumor (PT) on the immune activity and metastatic status of sentinel lymph nodes (SLNs) in melanoma patients.
- It finds that SLNs removed shortly after PT (IM-SLNs) show a higher incidence of micrometastases and lower immune activity compared to those removed later (DEL-SLNs).
- Higher immune activity and the presence of specific immune cells in DEL-SLNs suggest that the timing of SLN removal influences prognosis, with DEL-SLNs indicating a worse outcome due to the melanoma's ability to evade immune responses.
Article Synopsis
- Mycosis fungoides (MF) is a common type of skin cancer that makes it hard to tell harmful T cells from normal ones.
- Researchers used single-cell RNA and T-cell receptor sequencing on skin samples from 12 MF patients, analyzing 18,630 T cells from 9 of them to distinguish between malignant and reactive cells.
- The study found unique gene signatures in malignant T cells that could help differentiate them from reactive T cells, revealing significant variations in cell characteristics among patients.
Article Synopsis
- Hydrochlorothiazide is a common diuretic used to manage conditions like high blood pressure, fluid retention from heart issues, and certain kidney disorders.
- Diuretics increase urine output and can lead to side effects, with major concerns being low blood volume and electrolyte imbalances, alongside rarer issues like skin reactions.
- The case involves an 86-year-old man who experienced lightheadedness and a worsening rash after starting hydrochlorothiazide, prompting an emergency room visit.