Electrical Cochlear Response Consistency from different Cochlear Implant Users.

The Electrical Cochlear Response (ECR) is a scalp potential recently described in the literature which offers an alternative approach for objective adaptation of Cochlear Implant (CI) to individual patient requirements. Thus it is necessary to know about the consistency of this response across implanted patients using devices with different design criteria. This work shows that the ECR wave shape morphology is not affected by CI manufacture design differences.

Simulation of the Physiological Characteristics of Pillar and Modiolar Fibers of the Auditory Nerve.

The study of the physiological characteristics of the auditory nerve fibers is fundamental to understand their capability to encode sounds. These characteristics include their spontaneous firing rate, their threshold, and their dynamic range. Although it is possible to perform in vitro recordings of these characteristics in different cell models, it is complicated to obtain in vivo measurements of them directly from the cochlea.

Simulation of the efficiency of inner hair cell secretion in the auditory pathway.

Sound coding involves several stages of processing along the auditory path. Specifically, the Inner Hair Cells (IHC) act as sensory receptors and transduce acoustic information -frequency, intensity and duration of the stimulus- into neuronal signals. In this work, a stochastic model was implemented to achieve a better understanding of the IHC-auditory nerve synapse, specifically, the process of Ready Releasable Pool (RRP) vesicle exocytosis, a complicated process to study experimentally because current protocols do not provide adequate temporal resolution, in the order of milliseconds.

Cochlear implant artifact reduction on one channel Mismatch Negativity recordings based on Ensemble Empirical Mode Decomposition and Independent Component Analysis.

Artifact generated by cochlear implants has been a problem for being able to register Mismatch Negativity (MMN) response. There are methods for reducing the artifact using multiple channels from the EEG but in this paper are presented the first results of a method using only the channel with the artifact using Ensemble Empirical Mode Decomposition (EEMD) and Independent Component Analysis (ICA). The first results showed that it was possible to get the MMN registers from the group of normal recordings and partially with the group of recordings from patients with cochlear implant.

Acoustic evaluation of pirfenidone on patients with combined pulmonary fibrosis emphysema syndrome.

The combined pulmonary fibrosis emphysema syndrome (CPFES) overall has a poor prognosis with a 5-year survival of 35-80%. Consequently, to evaluate possible positive effects on patients of novel agents as pirfenidone is relevant. However, the efficacy of pirfenidone in CPFES patients is still not well-known.