Publications by authors named "N Carreras"
Objective: Segmentation of brain sulci in pre-term infants is crucial for monitoring their development. While magnetic resonance imaging has been used for this purpose, cranial ultrasound (cUS) is the primary imaging technique used in clinical practice. Here, we present the first study aiming to automate brain sulci segmentation in pre-term infants using ultrasound images.
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- Aging biomarkers can help researchers quickly assess the effects of aging interventions, bypassing the need for long-term studies, but their effectiveness as surrogate endpoints needs validation.
- Epigenetic clocks, which are developed from DNA methylation patterns, show promise in this area and are being investigated for their responsiveness to various aging interventions.
- The TranslAGE-Response database compiles data from numerous studies to identify patterns in how different interventions affect epigenetic clocks, revealing that some interventions have consistent effects while others do not, and highlighting the importance of considering study population and duration in these assessments.
Reactivation of retroelements in the human genome has been linked to aging. However, whether the epigenetic state of specific retroelements can predict chronological age remains unknown. We provide evidence that locus-specific retroelement DNA methylation can be used to create retroelement-based epigenetic clocks that accurately measure chronological age in the immune system, across human tissues, and pan-mammalian species.
View Article and Find Full Text PDFEffect of Cerebral Oximetry-Guided Treatment on Brain Injury in Preterm Infants as Assessed by Magnetic Resonance Imaging at Term Equivalent Age: An Ancillary SafeBoosC-III Study.
Neonatology
June 2024
Introduction: The SafeBoosC-III trial investigated the effect of cerebral oximetry-guided treatment in the first 72 h after birth on mortality and severe brain injury diagnosed by cranial ultrasound in extremely preterm infants (EPIs). This ancillary study evaluated the effect of cerebral oximetry on global brain injury as assessed by magnetic resonance imaging (MRI) at term equivalent age (TEA).
Methods: MRI scans were obtained between 36 and 44.
Human endogenous retroviruses (HERVs), the remnants of ancient viral infections embedded within the human genome, and long interspersed nuclear elements 1 (LINE-1), a class of autonomous retrotransposons, are silenced by host epigenetic mechanisms including DNA methylation. The resurrection of particular retroelements has been linked to biological aging. Whether the DNA methylation states of locus specific HERVs and LINEs can be used as a biomarker of chronological age in humans remains unclear.
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