The relationship between social deprivation and a frailty index of cumulative deficits in French middle-aged caregivers.

Background: The Institut Pasteur de Lille, in the north of France, has implemented a large, multidisciplinary health check, which aims to identify frailty in middle-aged caregivers. We aimed to construct an adapted frailty index of cumulative deficit (FI-CD) and study the associated factors, in particular socioeconomic factors.

Methods: The cross-sectional study included caregivers aged 45 to 65.

EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures.

Regulatory DNA elements, short genomic segments that regulate gene expression, have been implicated in developmental disorders and human disease. Despite this clinical urgency, only a small fraction of the regulatory DNA repertoire has been confirmed through reporter gene assays. The overall success rate of functional validation of candidate regulatory elements is low.

[To a margin reduction in the dermatofibrosarcoma protuberans? Retrospective study of 34 cases].

Introduction: The dermatofibrosarcoma protuberans (DFSP) is a rare but not exceptional tumour. Surgical treatment should contain a wide excision to avoid local recurrence.

Material And Method: We report a retrospective study of 34 cases treated by the same team from 1994 to 1999.

[Synthesis of the standard of treatment of cleft lip and cleft palate by 11 francophone teams en 2001].

Influenced by Eurocleft project, the authors proposed a synthesis of the protocol of treatment for cleft palate and/or cleft lip patient by 11 french and belgian teams. If the goal are similar (restored anatomy with good appearance, good speech, normal hearing, facial growth and dental arch correct, good social integration) the methods to obtain this outcome are different in each cleft unit. Consensual points and dissensions were described in the discussion.

[Surgery for craniosynostosis: timing and technique].

Craniosynostoses are a group of diseases, the presentation of which differs markedly on account of the cranial suture involved. Their impact is cosmetic, cerebral, and ophthalmologic. Syndromic craniosynostoses associate a more or less pronounced faciostenosis, which requires surgical correction as well, because of cosmetic, ophthalmologic or airway problems.