Publications by authors named "N Capoluongo"
Article Synopsis
- Sepsis is a serious health problem that affects the immune system during infections, and the study checked if a treatment using special antibodies (pentameric IgM) along with antibiotics helps patients recover after major surgeries.
- The study looked at 44 patients in total, with half getting both treatments and the other half getting antibiotics alone. They measured various health indicators over time to see how well they were doing.
- The results showed no real benefits from using pentameric IgM; both groups had similar outcomes, and the group that only used antibiotics responded faster in the first couple of days.
Introduction: Real-world safety studies can provide important evidence on the thromboembolic risk associated with COVID-19 vaccines, considering that millions of people have been already vaccinated against COVID-19. In this study, we aimed to estimate the incidence of thromboembolic events after COVID-19 vaccination and to compare the Oxford-AstraZeneca vaccine with other COVID-19 vaccines.
Methods: We conducted a retrospective real-world safety study using data from two different data sources: the Italian Pharmacovigilance database (Rete Nazionale di Farmacovigilanza, RNF) and the Campania Region Health system (Sistema INFOrmativo saNità CampanIA, SINFONIA).
Tixagevimab-cilgavimab is effective for the treatment of early COVID-19 in outpatients with risk factors for progression to severe illness, as well as for primary prevention and post-exposure prophylaxis. We aimed to retrospectively evaluate the hospital stay (expressed in days), prognosis, and negativity rate for COVID-19 in patients after treatment with tixagevimab-cilgavimab. We enrolled 42 patients who were nasal swab-positive for SARS-CoV-2 (antigenic and molecular)-both vaccinated and not vaccinated for COVID-19-hospitalized at the first division of the Cotugno Hospital in Naples who had received a single intramuscular dose of tixagevimab-cilgavimab (300 mg/300 mg).
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- - The ESCMID-EUCIC guideline advises against routine decolonization of multidrug-resistant Gram-negative bacteria due to insufficient evidence and calls for more robust clinical trials.
- - A scoping review was conducted from studies published between January 2017 and December 2021 to analyze the effectiveness and safety of decolonization therapies for drug-resistant Enterobacteriaceae, using a PICO framework for selection.
- - Out of 679 initial records, only 12 clinical studies were relevant: 4 were randomized trials and 8 were non-randomized, primarily focusing on digestive tract or oropharyngeal decontamination, highlighting the need for more well-designed research in this area.
Antimicrobial resistance (AMR) represents a major issue in healthcare being correlated to global inappropriate use of antibiotics. The aim of this study was to compare the data on hospital antibiotic consumption in 2020-2021 with those related to 2019 in order to evaluate the impact of the COVID-19 pandemic on antibiotic prescriptions and appropriate use at national level and in the different geographical areas. To estimate the consumption of antibiotics, two indicators were calculated: "number of DDD per 1000 inhabitants per day" and "number of DDD per 100 hospitalisation days".
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