Publications by authors named "N Callewaert"
Clin Epigenetics
December 2024
Article Synopsis
- Aberrant embryo implantation and placentation can lead to serious pregnancy complications like preeclampsia, and current risk identification methods are not very accurate.
- The ExPECT study aims to validate a cell-free DNA methylation strategy to diagnose preeclampsia early and identify high-risk pregnancies by analyzing blood samples over time.
- Results showed distinct methylation patterns between healthy and affected pregnancies, with significant differences detectable as early as 12 weeks, leading to the development of promising classification models for diagnosis and prediction.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a highly lethal cancer with a low 5-year survival rate, highlighting the need for effective monitoring and prognosis.
- A systematic review analyzed 3,904 studies to investigate if N-glycomics can predict HCC risk and survival in adults with chronic liver disease, ultimately including 30 studies in the analysis.
- The findings suggest that changes in N-glycans, particularly the Mac-2 binding protein glycosylation isomer (M2BPGi), are valuable indicators for predicting HCC development and patient prognosis.
Cell Host Microbe
October 2024
Article Synopsis
- Human myxovirus resistance 2 (MX2) inhibits HIV-1 and herpesviruses post-entry by interacting with viral capsids.
- Researchers identified that MX2 interacts with numerous FG-rich proteins and forms multiprotein condensates essential for its antiviral activity.
- These condensates trap the viral capsids and disrupt their entry into the nucleus, effectively preventing the viruses from delivering their genomes into host cells.
Arthritis Rheumatol
September 2024
Article Synopsis
- The study investigates how glycan modifications on IgG antibodies affect their role in inflammation, focusing on patients with primary Sjögren disease (SjD).
- Researchers analyzed IgG glycosylation in 300 patients, finding lower levels of sialylation and galactosylation in those with SjD compared to asymptomatic individuals; these changes correlate with increased B cell activation and various autoantibody profiles.
- The findings suggest that IgG Fc glycosylation could serve as a new marker for predicting disease progression, monitoring activity, and assessing lymphoma risk in SjD patients.
Article Synopsis
- 3% to 5% of cancer patients have cancer of unknown primary (CUP), making it difficult to determine the origin of their tumors.
- A new technique called cell-free reduced representation bisulfite sequencing (cfRRBS) can analyze DNA methylation patterns from small, fragmented samples, allowing for better classification of tumors, including CUP.
- The study showed that this method could accurately diagnose CUP in a significant number of samples, suggesting it could be a valuable tool alongside traditional cytology for cancer diagnosis.
