Patterns and Correlates of Bone Mineral Density Parameters Measured Using Calcaneus Quantitative Ultrasound in Chinese Adults.

Monitoring bone mineral density (BMD) in adults is critical for early detection of osteoporosis and prevention of fracture, for which quantitative ultrasound (QUS) is a good non-invasive tool. We examined the associations of QUS measures, including stiffness index (SI) and T-score, with socio-demographic, lifestyle, and anthropometric correlates and risk of subsequent fracture. : Calcaneal QUS was performed using GE's Lunar Achilles EXPII among 24,651 adults (mean age 59.

PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD.

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the repeat expansion in C9ORF72. Dipeptide repeat (DPR) proteins translated from both sense and antisense repeats, especially arginine-rich DPRs (R-DPRs), contribute to neurodegeneration. Through CRISPR interference (CRISPRi) screening in human-derived neurons, we identified receptor-type tyrosine-protein phosphatase S (PTPσ) as a strong modifier of poly-GR-mediated toxicity.

Implementing the 'Integrated Model for Supervision' for mental health and psychosocial support programming within humanitarian emergencies: A mixed-methods evaluation across six humanitarian contexts.

Background: The 'Integrated Model for Supervision' (IMS) offers important guidance for how to provide supportive supervision within mental health and psychosocial support (MHPSS) programming in humanitarian emergencies. The current study sought to (i) describe how the IMS was implemented following IMS training; (ii) assess whether delivery of the IMS training is associated with changes in a selection of theoretically supported quantitative outcomes; and (iii) elicit feedback on the IMS and its implementation process.

Methods: Data was collected from a participant pool of n = 119 individuals from six different humanitarian organisations that had previously participated in an IMS training.

Inborn errors of immunity in Canadian First Nations and Nunavut Inuit Children: the tip of the iceberg.

Objectives: Inborn errors of immunity (IEI) are a heterogeneous group of genetic diseases that impact normal immune development and function. Individual IEI are rare, but collectively, can represent an important health burden. Little is known about the types of IEI seen in Canadian First Nations (FN) and Inuit populations.

Acute Impact of Nonoptimal Ambient Temperatures on Plasma Levels of 3000 Proteins in Chinese Adults.

Nonoptimal ambient temperatures (i.e., cold and heat) are leading environmental determinants of major diseases worldwide, but the underlying pathological mechanisms are still poorly understood.