Monitoring bone mineral density (BMD) in adults is critical for early detection of osteoporosis and prevention of fracture, for which quantitative ultrasound (QUS) is a good non-invasive tool. We examined the associations of QUS measures, including stiffness index (SI) and T-score, with socio-demographic, lifestyle, and anthropometric correlates and risk of subsequent fracture. : Calcaneal QUS was performed using GE's Lunar Achilles EXPII among 24,651 adults (mean age 59.
View Article and Find Full Text PDFThe most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the repeat expansion in C9ORF72. Dipeptide repeat (DPR) proteins translated from both sense and antisense repeats, especially arginine-rich DPRs (R-DPRs), contribute to neurodegeneration. Through CRISPR interference (CRISPRi) screening in human-derived neurons, we identified receptor-type tyrosine-protein phosphatase S (PTPσ) as a strong modifier of poly-GR-mediated toxicity.
View Article and Find Full Text PDFBackground: The 'Integrated Model for Supervision' (IMS) offers important guidance for how to provide supportive supervision within mental health and psychosocial support (MHPSS) programming in humanitarian emergencies. The current study sought to (i) describe how the IMS was implemented following IMS training; (ii) assess whether delivery of the IMS training is associated with changes in a selection of theoretically supported quantitative outcomes; and (iii) elicit feedback on the IMS and its implementation process.
Methods: Data was collected from a participant pool of n = 119 individuals from six different humanitarian organisations that had previously participated in an IMS training.
Objectives: Inborn errors of immunity (IEI) are a heterogeneous group of genetic diseases that impact normal immune development and function. Individual IEI are rare, but collectively, can represent an important health burden. Little is known about the types of IEI seen in Canadian First Nations (FN) and Inuit populations.
View Article and Find Full Text PDFNonoptimal ambient temperatures (i.e., cold and heat) are leading environmental determinants of major diseases worldwide, but the underlying pathological mechanisms are still poorly understood.
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