Small molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cells.

Dysregulated eIF4E-dependent translation is a central driver of tumorigenesis and therapy resistance. eIF4E binding proteins (4E-BP1/2/3) are major negative regulators of eIF4E-dependent translation that are inactivated in tumors through inhibitory phosphorylation or downregulation. Previous studies have linked PP2A phosphatase(s) to activation of 4E-BP1.

Persistent post COVID-19: Implications for women's health research and policy from members of the Women's Health Expert Panel of the American Academy of Nursing.

Background: Despite that globally the percent of women and men who tested positive for COVID-19 appears equal and that men with COVID-19 were 60% more likely than women to be severely ill and to die from complications (Rozenberg et al., 2020), studies of sex differences show that women compared with men are more likely to manifest persistent post-COVID-19 syndrome (PPCS).

Purpose: In this paper, we address some of the extant evidence for impact of the PPCS on women's health and well-being to underpin our suggestions for research and policy considerations.

Mind-Body Interventions Impact Patient Anxiety Levels After Total Knee Arthroplasty (TKA): A Pilot Study.

Background: Orthopedic surgery can trigger anxiety that negatively impacts patient experience and recovery.

Purpose: This pilot study investigated if a compassionate interaction combined with standardized mind-body techniques could reduce patient anxiety levels during the initial postoperative phase for patients undergoing a total knee arthroplasty (TKA).

Methods: Participants were 36 postsurgical hospital inpatients guided through a 10-minute mind-body breathing and visualization intervention on post-op day zero (POD 0) and on post-op day one (POD 1).

SART1 modulates poly-(ADP-ribose) chain accumulation and PARP1 chromatin localization.

PARP1 inhibitors (PARPis) are used for treatment of cancers with mutations in or that are deficient in homologous recombination. The identification of modulators of PARP1 activity is critical to understand and overcome resistance to PARPis. We integrated data from three omics-scale screens to discover new regulators of PARP1 activity.

How to ensure an appropriate oral health workforce? Modelling future scenarios for the Netherlands.

Background: Current methods for oral health workforce planning lack responsiveness to dynamic needs, hampering efficiency, equity and sustainability. Effective workforce planning is vital for resilient health care systems and achieving universal health coverage. Given this context, we developed and operationalised a needs-adaptive oral health workforce planning model and explored the potential of various future scenarios.