Neurofilament Light Chain as a Discriminator of Disease Activity Status in MOG Antibody-Associated Disease.

Background And Objectives: In patients with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), acute disease activity is generally identified through medical history, neurologic examination, and imaging. However, these may be insufficient for detecting disease activity in specific conditions. This study aimed to investigate the dynamics of serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) after clinical attacks and to assess their utility in discriminating attacks from remission in patients with MOGAD.

Embracing the other: Revisiting the epistemological foundations of family systems therapy.

Family systems therapy originated in the 1960s, 1970s, and 1980s through the work of innovative thinkers and clinicians. However, despite the creative contributions of the mentioned colleagues and of later innovations in family therapy theory and practice, it seems as though the dominant culture of establishment psychiatry in the United States (and in most Western countries) to this day has not seriously incorporated relationships, social context, or community connectedness into the treatment of individuals with psychiatric diagnoses. For the "psychiatric" patients diagnosed according to the DSM-5, the dominant underlying epistemological perspective is the medical "scientific" paradigm.

Somatosensory omissions reveal action-related predictive processing.

The intricate relation between action and somatosensory perception has been studied extensively in the past decades. Generally, a forward model is thought to predict the somatosensory consequences of an action. These models propose that when an action is reliably coupled to a tactile stimulus, unexpected absence of the stimulus should elicit prediction error.

On the relationship of arousal and attentional distraction by emotional novel sounds.

Unexpected and task-irrelevant sounds can impair performance in a task. It has been shown that highly arousing emotional distractor sounds impaired performance less compared to moderately arousing neutral distractor sounds. The present study tests whether these differential emotion-related distraction effects are directly related to an enhancement of arousal evoked by processing of emotional distractor sounds.

Salient omissions-pupil dilation in response to unexpected omissions of sound and touch.

Introduction: Recent theories describe perception as an inferential process based on internal predictive models adjusted by means of prediction violations (prediction error). To study and demonstrate predictive processing in the brain the use of unexpected stimulus omissions has been suggested as a promising approach as the evoked brain responses are uncontaminated by responses to stimuli. Here, we aimed to investigate the pupil's response to unexpected stimulus omissions in order to better understand surprise and orienting of attention resulting from prediction violation.