Static Posture Instability as a Sensitive Biomarker for Motor Abnormalities in Pre-ataxic Spinocerebellar Ataxia Type 3 Patients.

Background: Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder, with balance instability as a feature of the disease. Balance instability often manifests before the onset of obvious ataxic symptoms in patients. However, current clinical scales exhibit limited sensitivity in characterizing changes in pre-ataxic patients.

Biofunctionalized patterned platform as microarray biochip to supervise delivery and expression of pDNA nanolipoplexes in stem cells via mechanotransduction.

Biochips are widely applied to manipulate the geometrical morphology of stem cells in recent years. Patterned antenna-like pseudopodia are also probed to explore the influence of pseudopodia formation on gene delivery and expression on biochips. However, how the antenna-like pseudopodia affect gene transfection is unsettled and the underlying trafficking mechanism of exogenous genes in engineered single cells is not announced.

Association of thrombus enhancement with mortality following endovascular therapy in patients with acute anterior circulation stroke.

Background: Thrombus enhancement sign (TES) has emerged as a potential imaging biomarker in patients with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT).

Objective: To evaluate the prognostic value of TES on 90-day mortality and functional outcomes.

Methods: We conducted a prospective, two-center study involving 323 patients with AIS treated with EVT.

The interactive toxic effect of homocysteine and copper on cardiac microvascular endothelial cells during ischemia-reperfusion injury.

Hyperhomocysteinemia (HHcy) is associated with the development and progression of chronic cardiovascular diseases through the deleterious effects of high levels of homocysteine (Hcy) on the cardiovascular system. However, the exact mechanism of action of Hcy on the acute injury of the cardiovascular system following ischemia/reperfusion (I/R) remains unclear. The present study demonstrated that copper mobilization occurs during cardiac I/R, and the interactive toxic effect of Hcy and mobile Cu during cardiac I/R induces necroptosis of cardiac microvascular endothelial cells (CMECs) and thus enhances cardiac dysfunction.

Fish migration modeling and habitat assessment in a complex fluvial system.

Fish migration patterns are driven by hydrodynamic factors, which are essential in aquatic ecology. This study investigated the hydrodynamic drivers of Gymnocypris przewalskii fish migration in two distinct river reaches-a straight reach (SR) and a confluence reach (CR)- in the area of Qinghai Lake, China, using a 3D numerical model, fish density field data, and four predictive models. Thirteen hydrodynamic factors, with a focus on water depth and velocity, were analyzed to identify their influence on fish migration.