Publications by authors named "N C Sivakumar"
Objective: Artificial intelligence (AI) tools for histological diagnosis offer great potential to healthcare, yet failure to understand their clinical context is delaying adoption. IGUANA (Interpretable Gland-Graphs using a Neural Aggregator) is an AI algorithm that can effectively classify colonic biopsies into normal versus abnormal categories, designed to automatically report normal cases. We performed a retrospective pathological and clinical review of the errors made by IGUANA.
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- Understanding posture is crucial for how mammals move, and dysregulation of certain brain chemicals, specifically dopamine and noradrenaline, can lead to motor problems in diseases like spinal muscular atrophy (SMA).
- Research using a mouse model of SMA revealed that the loss of synapses in the spinal neurons, caused by non-cell autonomous mechanisms, contributes to motor dysfunction and postural issues.
- Restoring a specific protein (survival motor neuron) in either catecholaminergic or serotonergic neurons can improve movement, but significant postural issues only improve with restoration in both neuron types or treatment with l-dopa, highlighting new potential treatment strategies.
This study investigates the biodegradation of methyl parathion, an organophosphate pesticide used in paddy fields. Microbial degradation transforms toxic pesticides into less harmful compounds, influenced by the microbial community in the soil. To isolate different microbial colonies, soil samples from an organophosphorus-treated groundnut field were plated on nutrient agar and MSM with 1% glucose and 0.
View Article and Find Full Text PDFBackground: Trace elements are the important components that play a crucial role in various functions of the human body at cellular and molecular levels. Considering the role of the trace elements in precancerous and cancerous conditions, estimation of their levels in these conditions could aid in understanding the disease process and progression. The purpose of this study is to determine the alteration in salivary electrolyte concentration of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) patients to correlate the variations with the severity and biological behaviour.
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- Oral cancer is the 16th most common cancer globally, with high prevalence in Southeast Asia due to tobacco use, prompting a study of chemokines involved in the disease.
- The research focused on immunohistochemical expression of CCL28 and its receptor CCR10 in oral squamous cell carcinoma (OSCC), examining 50 OSCC tissue samples and 50 normal oral mucosa samples for comparison.
- Findings revealed a strong correlation between CCL28 and CCR10 expression in OSCC, highlighting their potential as prognostic biomarkers for understanding tumor progression in the disease.