Tanshinone IIA from Salvia miltiorrhiza alleviates follicular maturation arrest symptoms in zebrafish via binding to the human androgen receptors and modulating Tox3 and Dennd1a.

Follicular maturation arrest is a prevalent endocrine disorder characterized by hormonal imbalance, ovarian dysfunction, and metabolic disturbances leading to Polycystic ovarian syndrome (PCOS). Tanshinone IIA (TIIA), a bioactive compound derived from Salvia miltiorrhiza, has shown promising therapeutic potential in various diseases, including cardiovascular diseases and cancer. However, its effects on reproductive health and gynecological disorders, particularly PCOS, remain poorly understood.

Impact of COVID-19 lockdown on the particulate matter over Perungudi, Chennai, India.

The nationwide lockdown of Phase-1 in India was started from March 25 to April 14, 2020 and Phase-2 from April 15 to May 3, 2020 with severe restrictions on public activities in India. Utilizing the particulate matter PM and PM data recorded during this adverse time, the present study is undertaken to assess the impact of phase 1 and 2 lockdown on the air quality of Perungudi, Chennai, India. The data obtained from the Tamil Nadu Pollution Control Board was assessed for lockdown phase.

Influence of biodiesel-diesel-hexanol and biodiesel-diesel-ethanol blends on compression ignition engine performance, combustion and emission characteristics.

In the current work, the influences of biodiesel-diesel-hexanol and biodiesel-diesel-ethanol blends on compression ignition engine characteristics were experimentally investigated. Experiments were conducted on a diesel engine at 0%, 25%, 50%, 75% and 100% load conditions run at a constant speed of 1500 rpm. The results revealed that B90-D5-H5 acquired the lowest BSFC and maximum BTE of 0.

Molecular evolution of single chain fragment variable (scFv) for diagnosis of lymphatic filariasis.

Endemic countries with lymphatic filariasis are striving towards the Global Program to Eliminate Lymphatic Filariasis (GPELF) by 2020. Efficient and cost-effective diagnostic tools to assess active filarial infection are critical to eradicate lymphatic filariasis. Detection of circulating filarial antigens in sera is one of the precise methods to identify this infection.