Publications by authors named "N C M Visser"
The catalytic and plasmonic properties of bimetallic gold-palladium (Au-Pd) nanoparticles (NPs) critically depend on the distribution of the Au and Pd atoms inside the nanoparticle bulk and at the surface. Under operating conditions, the atomic distribution is highly dynamic. Analyzing gas induced redistribution kinetics at operating temperatures is therefore key in designing and understanding the behavior of Au-Pd nanoparticles for applications in thermal and light-driven catalysis, but requires advanced characterization strategies.
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- The study explores how the PD-1 immune checkpoint protein is regulated on CD8 T cells, aiming to find ways to lower its abundance without hindering T cell activation, which is crucial for effective cancer therapy.
- Researchers conducted a CRISPR-Cas9 screen on murine CD8 T cells to identify genes impacting PD-1 levels, discovering that inhibiting the TMED protein family, especially TMED10, could reduce PD-1 on the cell surface and enhance T cell function.
- The findings highlight a new regulatory mechanism for PD-1 and suggest that targeting TMED could be a promising therapeutic strategy to improve T cell responses in cancer treatment, as indicated by correlations in mouse models and patient survival data.
Phthalate monoesters have been identified as endocrine disruptors in a variety of models, yet understanding of their exact mechanisms of action and molecular targets in cells remains incomplete. Here, we set to determine whether epidemiologically relevant mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) can affect biological processes by altering cell plasma membrane fluidity or formation of cell-cell contacts. As a model system, we chose endometrial stromal cell lines, one of which was previously used in a transcriptomic study with MEHHP or MEHHP-containing mixtures.
View Article and Find Full Text PDFPhthalates are endocrine disrupting chemicals (EDCs) found in common consumer products such as soft plastics and cosmetics. Although the knowledge regarding the adverse effects of phthalates on female fertility are accumulating, information on the hormone sensitive endometrium is still scarce. Here, we studied the effects of phthalates on endometrial cell proliferation and gene expression.
View Article and Find Full Text PDFLate-onset corneal edema after customized crosslinking for progressive keratoconus.
Am J Ophthalmol Case Rep
September 2024
Purpose: We describe a patient after customized crosslinking (CXL) for progressive keratoconus who developed corneal edema with spontaneous resolution.
Observations: A 24-year-old male with progressive keratoconus of the left eye underwent a customized CXL procedure with a total energy of 10 J/cm for 16.4 minutes.