Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective Na1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain.

Introduction: There is a high unmet need for safe and effective non-opioid medicines to treat moderate to severe pain without risk of addiction. Voltage-gated sodium channel 1.8 (Na1.

Phase I/II Trial of Perioperative Avelumab in Combination With Chemoradiation in the Treatment of Stage II/III Resectable Esophageal and Gastroesophageal Junction Cancer.

Background And Objectives: Standard treatment of patients with stage II/III esophageal or gastroesophageal junction (E/GEJ) cancer involves neoadjuvant chemoradiation (nCRT), resection, and immunotherapy. Our trial evaluated the addition of perioperative avelumab to standard treatments.

Methods: Patients with resectable E/GEJ cancers received avelumab with nCRT and adjuvant avelumab after resection.

Tokamak Plasmas with Density up to 10 Times the Greenwald Limit.

Current-carrying, toroidal laboratory plasmas typically cannot be sustained with an electron density above the empirical Greenwald limit. Presented here are tokamak experiments in the Madison Symmetric Torus with a density up to an unprecedented level about 10 times this limit. This is thought to be made possible in part by a thick, stabilizing, conductive wall, and a high-voltage, feedback-controlled power supply driving the plasma current.

All-in-one probe for exploring self-organized two-fluid equilibria in toroidal plasmas.

This paper presents the development of an all-in-one probe to simultaneously measure all components of the generalized Ohm's law in reversed-field pinch plasmas and tokamaks. The polyhedral configuration of the Mach probe is achieved through the specific arrangement, angle, and depth of the collimator channel apertures drilled into the surface of a hollow boron nitride cylinder encasing it. This probe includes a central Mach probe to assess the ion velocity field in three dimensions.