Publications by authors named "N C Gutierrez"
Antiapoptotic Bcl-2 family proteins are involved in myeloma cell survival. To date, their expression in multiple myeloma (MM) patients has mostly been analyzed at the RNA level. In the present study, we quantified for the first time the protein expression of the Bcl2-family members using a capillary electrophoresis immunoassay in 120 newly diagnosed MM patients, aged ≤65 years, treated in the context of the PETHEMA/GEM2012 study.
View Article and Find Full Text PDFThis study examines the impact of cytogenetic abnormalities and their co-segregation on the prognosis of newly diagnosed multiple myeloma patients. The analysis included 1304 patients from four different GEM-PETHEMA clinical trials. Genetic alterations, such as t(4;14), t(14;16), del(17p), +1q, and del(1p), were investigated using FISH on CD38 purified plasma cells.
View Article and Find Full Text PDFArticle Synopsis
- - Glomus tumors (GT) are rare tumors that originate from glomus bodies in the skin and play a role in regulating body temperature, with most being benign but some showing aggressive and malignant behavior.
- - Malignant glomus tumors can spread and respond poorly to standard chemotherapy, but certain cases have a mutation (BRAF V600E) that offers a potential treatment target.
- - This report highlights a case of a metastatic glomangiosarcoma with the BRAF V600E mutation that showed significant improvement after being treated with encorafenib and binimetinib.
Article Synopsis
- Bovine viral diarrhea virus (BVDV) is bad for cattle and costs farmers money because it makes their cows less healthy and requires expensive control programs.
- Scientists created a new test called rE2-ELISA to find BVDV by using special proteins from the virus, making it easier to spot different types of BVDV around the world.
- The rE2-ELISA test works really well, being over 92% accurate, and can help farmers quickly identify sick animals, which is important for keeping herds healthy.