Publications by authors named "N C Godwin"
Background/objectives: Ketone esters (KEs) exhibit promise as anti-cancer agents but their impact on spontaneous metastases remains poorly understood. Although consumption of a ketogenic diet (KD) that is low in carbohydrates and high in fats can lead to KE production in vivo, the restrictive composition of KDs may diminish adherence in cancer patients.
Methods: We investigated the effects of an exogenous ketone ester-supplemented (eKET), carbohydrate-replete diet on tumor growth, metastasis, and underlying mechanisms in orthotopic models of metastatic breast (4T1-Luc) and renal (Renca-Luc) carcinomas.
We previously demonstrated that the overall number of regulatory T (Treg) cells decrease proportionately with helper CD4 T cells and their frequencies increase in antiretroviral therapy (ART)-naive human immunodeficiency virus type-1 (HIV-1) infected individuals. The question now is whether the discrepancies in Treg cell numbers and frequencies are synonymous to an impairment of their functions. To address this, we purified Treg cells and assessed their ability to modulate autologous monocytes functions.
View Article and Find Full Text PDFMalaria blood-stage parasite is a critical pathogenic stage responsible for serious adverse outcomes in pregnant women and their neonates. Immunoglobulin G (IgG) antibody responses specific to various asexual blood-stage antigens were well reported in non-pregnant individuals. However, little is still known during placental malaria.
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- Internally displaced persons (IDPs) in Northeast Nigeria face heightened COVID-19 infection risks due to unsanitary living conditions, making accurate information and knowledge crucial for effective preventive measures.
- A study conducted from July to December 2022 surveyed 2,175 IDPs, assessing their COVID-19 knowledge and risk perceptions using a structured tool and statistical analyses.
- Results showed that only 32% of participants had adequate COVID-19 knowledge, while over half perceived a high risk of infection; higher knowledge and education levels were linked to better risk perception and adherence to preventive measures like vaccination and mask-wearing.
Article Synopsis
- - Over two million internally displaced persons (IDPs) in northeastern Nigeria face high health risks due to poor living conditions, prompting a study to analyze their health-seeking behaviors for better disease response strategies.
- - A study involving 2,373 IDPs showed that most sought care at health facilities (75.7%), while a smaller percentage turned to non-facility options (11.1%) or home remedies/care (13.2%).
- - Key factors influencing health-seeking included the severity of perceived illness and whether the IDPs lived in officially recognized camps, with those in recognized camps and perceiving severe illness less likely to opt for non-facility care.