Protocol for a theory-based, mixed methods evaluation of Cynnau|Ignite: an active learning programme to foster positive research culture through leadership development at Cardiff University.

Number: ISRCTN15575518.

GNOme, an ontology for glycan naming and subsumption.

While GlyTouCan provides stable identifiers for referencing glycan structures, they are not organized semantically. GNOme, a glycan naming and subsumption ontology and a member of the OBOFoundry, organizes GlyTouCan accessions for automated reasoning and interactive browsing of glycan structures by subsumption. GNOme makes it quick and easy to discover glycans with a specific degree of characterization; provides a text-based table of common synonyms for specific structures and compositions; enumerates glycan subsumption relationships for automated reasoning; and assigns each glycan to well-defined categories based on their degree of characterization.

Transforming US agriculture for carbon removal with enhanced weathering.

Enhanced weathering (EW) with agriculture uses crushed silicate rocks to drive carbon dioxide removal (CDR). If widely adopted on farmlands, it could help achieve net-zero emissions by 2050. Here we show, with a detailed US state-specific carbon cycle analysis constrained by resource provision, that EW deployed on agricultural land could sequester 0.

Head and neck paraganglioma in Pacak-Zhuang syndrome.

Background: Head and neck paragangliomas (HNPGLs) are typically slow-growing, hormonally inactive tumors of parasympathetic paraganglia. Inactivation of prolyl-hydroxylase domain-containing 2 protein causing indirect gain-of-function of hypoxia-inducible factor-2α (HIF-2α), encoded by EPAS1, was recently shown to cause carotid body hyperplasia. We previously described a syndrome with multiple sympathetic paragangliomas caused by direct gain-of-function variants in EPAS1 (Pacak-Zhuang syndrome, PZS) and developed a corresponding mouse model.