Publications by authors named "N C Eastley"
We present a novel case of a malignant transformation of an extremity soft tissue angioleiomyoma to leiomyosarcoma in a man in his late 70s who presented with a painful and increasing lump on his anterior tibia. Initial imaging and biopsy showed a benign angioleiomyoma which was excised for symptomatic reasons. An analysis of the resulting specimen revealed a 50×42×15 mm smooth muscle neoplasm consistent with angioleiomyoma with a 22×11 mm entirely intralesional nodular component in keeping with a grade 1 leiomyosarcoma.
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- The study investigates the link between obesity and major wound complications in patients undergoing surgery for pelvic bone sarcoma, using data from surgeries performed between 2005 and 2021.
- Out of 93 patients reviewed, those with obesity (21 patients) experienced a higher rate of major wound complications (52%) compared to non-obese patients (26%), and also scored lower on functional outcomes after one year.
- The findings suggest that obesity is a significant independent risk factor for wound complications, emphasizing the need for thorough pre- and postoperative care for obese patients undergoing this type of surgery.
Background And Objectives: This multicenter retrospective series of consecutive extra-spinal aneurysmal bone cysts aims to identify risk factors for treatment failure.
Methods: Aneurysmal bone cysts treated within seven collaborating centers with over 12-months follow-up were eligible for inclusion. Survival analyses were performed to identify variables associated with recurrence using log-rank tests and Cox proportional hazard regression.
Background: Megaprosthetic replacement (MPR) of the femur is typically reserved for salvage or oncological reconstruction. Presently little is known about the provision of femoral MPRs performed nationally, the trends in indications for their use, and their outcomes beyond published unit-level data. Although the National Joint Registry (NJR) collects data as part of a mandatory arthroplasty audit process, MPR data entry on this platform is thought to be inconsistent.
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- Myxoid liposarcoma (MLS) primarily affects younger patients and is sensitive to radiation, leading to significant tumor reduction before surgery.
- A study analyzed 198 patients with localized, intermuscular MLS treated with pre-operative radiotherapy to see if the surgical margins impacted survival outcomes.
- Results showed that the status of surgical margins did not affect rates of local recurrence or overall survival, indicating that marginal resection is a safe option for this type of cancer.