Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism.

The dopamine (DA) system has a profound impact on reward-motivated behavior and is critically involved in neurodevelopmental disorders, such as autism spectrum disorder (ASD). Although DA defects are found in autistic patients, it is not well defined how the DA pathways are altered in ASD and whether DA can be utilized as a potential therapeutic agent for ASD. To this end, we employed a phenotypic and a genetic ASD model, i.

Cyberbiosecurity Implications for the Laboratory of the Future.

Technological innovation has become an integral and inescapable aspect of our daily existence as almost everything of significance in our world now has a cyber (i.e., relating to, or involving computers, computer networks, information technology, and virtual reality) component associated with it.

Evaluating binuclear copper(II) complexes for glycoside hydrolysis.

Three binuclear copper(II) complexes were characterized as solids by X-ray diffraction and in solution by UV/vis spectrophotometric titration, and subsequently evaluated for their glycosidase-like activity. The structure analysis revealed comparable intermetallic Cu..

Planning and organizing a multidisciplinary psychosocial oncology service.

Providing psychosocial care to patients with cancer and their families is a formidable task given the current fiscal environment in hospitals. As the pool of available resources shrinks and populations shift from inpatient to outpatient, psychosocial staff are challenged to find creative, versatile, and efficient ways to deliver quality services and programs. This article describes the efforts to plan and implement psychosocial care at a cancer center facing the constraints of limited staff and decreasing resources.

Good grieving--an intervention program for grieving children.

Purpose/objectives: To describe a program for grieving children including the agenda, activities, and logistics of organizing the program.

Data Sources: Clinical observations and evaluations from the program; literature review.

Data Synthesis: A series of four seasonal programs were designed to promote a child's normal grieving process and enhance adjustment to the loss.