Publications by authors named "N C Donner"
Article Synopsis
- Chronic B-cell receptor signals triggered by antigens are important for developing mucosa-associated lymphoid tissue lymphomas, particularly ocular adnexal MALT lymphomas (OAMLs).
- In a study of 124 OAMLs, researchers found that 5% expressed a high-affinity rheumatoid factor and that many had a specific bias toward using the IGHV4-34 immunoglobulin gene, which reacts with certain cellular epitopes.
- Additionally, some OAML-derived IgMs showed reactivity with proteins associated with autoimmune diseases, suggesting that local autoimmune responses contribute significantly to the development of a notable portion of OAMLs.
Introduction: There is limited literature on the prevalence of EGFR mutations in early stage NSCLC. EARLY-EGFR (NCT04742192), a cross-sectional study, determined the prevalence of EGFR mutations in early stage NSCLC.
Methods: This noninterventional, real-world study enrolled consecutive patients with resected stages IA to IIIB (American Joint Committee on Cancer eighth edition) NSCLC from 14 countries across Asia, Latin America, and the Middle East and Africa.
This case report highlights a case of extranodal NK/T cell lymphoma initially misdiagnosed as myositis, emphasizing the appearance on both MRI and FDG PET images. The patient presented with systemic symptoms and calf muscle swelling, prompting imaging studies that revealed diffuse muscle involvement. Despite negative myositis markers and inconclusive biopsy, post-amputation findings confirmed lymphoma with EBV positivity.
View Article and Find Full Text PDFBackground: Cross-sectional relationships between psychosocial resilience factors (RFs) and resilience, operationalized as the outcome of low mental health reactivity to stressor exposure (low "stressor reactivity" [SR]), were reported during the first wave of the COVID-19 pandemic in 2020.
Objective: Extending these findings, we here examined prospective relationships and weekly dynamics between the same RFs and SR in a longitudinal sample during the aftermath of the first wave in several European countries.
Methods: Over 5 weeks of app-based assessments, participants reported weekly stressor exposure, mental health problems, RFs, and demographic data in 1 of 6 different languages.
Article Synopsis
- * This study examined GCs in human lymph nodes responding to unknown antigens, rather than in traditional mouse models with specific antigens.
- * The researchers found diverse B-cell clones in individual GCs but also identified shared clones, suggesting that these GCs can evolve similarly even when responding to different antigens.