Safety and immunogenicity of an acellular pertussis vaccine containing genetically detoxified pertussis toxin administered to pregnant women living with and without HIV and their newborns (WoMANPOWER): a randomised controlled trial in Uganda.

Background: Immunisation in pregnancy against pertussis can reduce severe disease in infancy. There are few data on the safety and immunogenicity of vaccines given to pregnant women living with HIV and their infants. We aimed to describe the safety and immunogenicity of a tetanus-diphtheria-acellular pertussis (TdaP) vaccine containing genetically detoxified pertussis toxin given to pregnant women living with HIV and the effect of the vaccine on infant whole-cell pertussis vaccine responses.

Conceptual Confusion: A Barrier to Multi-Professional Involvement in Advance Care Planning in Nursing Homes - An Ethnographic Study.

Objectives: How health and social care professionals need to work together to deliver advance care planning (ACP) in nursing homes is not fully understood, with a reliance on professionals external to the nursing home to support ACP in the United Kingdom. The objectives of this study were to (a) examine the factors that influence multi-professional involvement in the ACP process within nursing homes and (b) explore how multi-professional working impacts the ACP process in nursing homes.

Methods: Using ethnography, data was collected through observation, interviews and document review from 36 participants including residents ( = 6), relatives ( = 4), nursing home staff ( = 19) and visiting professionals ( = 7).

Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes.

Boston Children's Hospital has established a genomic sequencing and analysis research initiative to improve clinical care for pediatric rare disease patients. Through the Children's Rare Disease Collaborative (CRDC), the hospital offers CLIA-grade exome and genome sequencing, along with other sequencing types, to patients enrolled in specialized rare disease research studies. The data, consented for broad research use, are harmonized and analyzed with CRDC-supported variant interpretation tools.

Finding the Right First Job: Academic.

Finding the right first academic sports medicine job is a complex undertaking. There are a number of factors that go into the decision, including finding the job opening, limited regional availability, various academic affiliations, and organizational nuances, as well as payment structures. This article details the many facets of academic sports medicine that make up a position and can greatly affect surgeon workflow, productivity, and overall happiness.