No Tumor Suppressor Role for in Prostate Cancer.

To elucidate the pathogenesis of prostate diseases, following analysis, the gene was selected for further investigation. The gene has been associated with poor prognosis and is frequently mutated in different types of cancers. In this study, 50 benign prostatic hyperplasia (BPH) and 57 prostate cancer (PCa) tissues, including matched normal tissue for the patients, were analyzed by qRT-PCR and DNA sequencing for expression and the mutation profile, respectively.

Vitamin D binding protein genotype frequency in familial Mediterranean fever patients.

: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent short episodes (1-3 days) of inflammation and fever. FMF is associated with gene mutations but some patients with FMF symptoms do not have a mutation in the coding region of the gene. Vitamin D binding protein (VDBP) has important functions, including transporting vitamin D and its metabolites to target cells.

Silencing of Wwox Increases Nuclear Import of Dvl proteins in Head and Neck Cancer.

: Wnt signaling pathway is associated with a variety of human cancers, including HNSCC. Wnt proteins control cellular events such as proliferation, fate specification, polarity, and migration by transducing signals to the nucleus through several cytoplasmic relay proteins. Although activation of the Wnt/β-catenin pathway is a frequent event in various cancers, there is limited knowledge on the contribution of this signaling mechanism in HNSCC.

Analysis of the DOK1 gene in breast cancer.

Breast cancer, which is the most common type of cancer among women, is a heterogenous disease. It results from progressive accumulation of genetic and epigenetic alterations in different genes. The Dok1 protein has been identified as the major substrate of protein tyrosine kinases in hematopoietic cells.