Publications by authors named "N Brose"
Transplantation of induced pluripotent stem cell-derived neural cells represents a promising strategy for treating neurodegenerative diseases. However, reprogramming of somatic cells and their subsequent neural differentiation is complex and time-consuming, thereby impeding autologous applications. Recently, direct transcription factor-based conversion of blood cells into induced neural stem cells (iNSCs) has emerged as a potential alternative.
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- - The study examines how synaptic changes in neuronal circuits may underlie memory storage, focusing on the structural evidence for synaptic engrams at the hippocampal mossy fiber synapse.
- - Researchers used a combination of chemical potentiation, functional recordings, and advanced microscopy techniques to assess the effects of forskolin on synaptic transmission and structure.
- - Findings revealed that forskolin increased both the number of readily releasable vesicles and their proximity to priming proteins, suggesting that structural reorganization at synaptic sites could correlate with learning and memory processes.
Article Synopsis
- The synaptic vesicle cluster (SVC) is critical for releasing neurotransmitters at chemical synapses and also helps regulate various cofactors involved in exo- and endocytosis.
- It contains various molecules important for synaptic processes, including cytoskeletal elements and adhesion proteins, and influences the positioning and activity of key organelles like mitochondria.
- Changes in the size of the SVC may align with alterations in the postsynaptic area, indicating that it plays a central role in synchronizing pre- and postsynaptic functions, which warrants further research into its regulatory mechanisms.
Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all GABAergic synapses, which recruits GABARs by promoting assembly of the postsynaptic gephyrin scaffold. Intriguingly, loss of Nlgn2 differentially affects subsets of GABAergic synapses, indicating that synapse-specific interactors and redundancies define its function, but the nature of these interactions remain poorly understood. Here we investigated how Nlgn2 function in hippocampal area CA1 is modulated by two proposed interaction partners, MDGA1 and MDGA2.
View Article and Find Full Text PDFIntroduction: The Anaphase Promoting Complex (APC/C), an E3 ubiquitin ligase, plays a key role in cell cycle control, but it is also thought to operate in postmitotic neurons. Most studies linking APC/C function to neuron biology employed perturbations of the APC/C activators, cell division cycle protein 20 (Cdc20) and Cdc20 homologue 1 (Cdh1). However, multiple lines of evidence indicate that Cdh1 and Cdc20 can function in APC/C-independent contexts, so that the effects of their perturbation cannot strictly be linked to APC/C function.
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