Zinc oxide, titanium dioxide and C fullerene nanoparticles, alone and in mixture, differently affect biomarker responses and proteome in the clam Ruditapes philippinarum.

Continuous release of nanoparticles (NPs) into marine coastal environments results in an increased risk of exposure to complex NP mixtures for marine organisms. However, to date, the information on the effects at molecular and biochemical levels induced by the exposure to NPs, singly and as a mixture, is still scant. The present work aimed at exploring the independent and combined effects and the mechanism(s) of action induced by 7-days exposure to 1 μg/L nZnO, 1 μg/L nTiO and 1 μg/L FC fullerene in the Manila clam Ruditapes philippinarum, using a battery of immunological and oxidative stress biomarkers in haemolymph, gills and digestive gland.

pneumonia in breast cancer mimicking SARS-CoV-2 pneumonia during pandemic.

pneumonia (PJP) is one of the most common HIV-related opportunistic infection. Apart from HIV patients, subjects treated with an associated therapy of high doses glucocorticoids and immunosuppressive drugs should be considered at risk. SARS-CoV-2 has become worldly known as the responsible of the pandemic that hit the world in late 2019 and that is still ongoing.

Bioaccumulation and effects of titanium dioxide nanoparticles and bulk in the clam Ruditapes philippinarum.

Biochemical and cellular responses to low concentrations of TiO nanoparticles (nTiO 1 and 10 μg/L) and bulk (bTiO, 10 μg/L) were evaluated in gills, digestive gland and haemolymph of the clam Ruditapes philippinarum after1, 3 and 7 days' exposure. At 7 days, titanium content was determined in gills and digestive gland. nTiO significantly increased antioxidant enzyme activities in both tissues, and lipid peroxidation in digestive gland at 10 μg/L only, and affected glutathione S-transferase activity.

Effectiveness of kidney transplantation in HIV-infected recipients under combination antiretroviral therapy: a single-cohort experience (Brescia, Northern Italy).

Purpose: Kidney transplantation was recently introduced for the treatment of end stage renal disease (ESRD) in HIV-infected patients. We report the results of the first 28 procedures at our centre.

Methods: A retrospective study was conducted on HIV-infected patients evaluated for kidney transplantation between January 2005 and October 2016.