Publications by authors named "N Breusing"
Article Synopsis
- Immune function declines with age, making it difficult to identify individuals at risk for immune-related issues, especially those with reactivated latent viral infections.
- The study focused on detecting certain human herpes viruses in urine as a potential way to identify immune-compromised individuals, particularly using T cell receptor excision circle (TREC) data as an indicator.
- While no clear one-to-one correlation was found between TREC values and individual viruses, a significant link was observed for males; specifically, low TREC values correlated with the detection of three or more different herpes viruses, suggesting declining immune function.
Article Synopsis
- - The study investigates the role of oxidized LDL particles (LDLox) in assessing cardiometabolic risk, focusing on their relationship with other biomarkers and risk factors using data from 1089 participants aged 40-75.
- - Researchers performed correlation analyses and developed machine learning models to predict risks associated with high blood pressure and obesity, achieving promising validation scores that highlighted the significance of LDLox.
- - The findings provide new insights into how LDL oxidation may interact with aging markers to influence cardiometabolic health, suggesting that further research with larger groups could enhance clinical assessment tools.
Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.
View Article and Find Full Text PDFGrowth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e.
View Article and Find Full Text PDFIntroduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population.
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