The role of lysophosphatidic acid and its receptors in corneal nerve regeneration.

The integrity of corneal nerves is critical for ocular surface health, and damages can lead to Neurotrophic Keratopathy (NK). Despite the regenerative abilities of the peripheral nerve system (PNS), corneal nerve regeneration is often incomplete, and the underlying mechanisms are poorly understood. This study aims to identify potential factors that can enhance corneal nerve regeneration for NK treatment, with a focus on Lysophosphatidic acid (LPA).

Older adult and caregiver needs for patient-centered outcomes research training in medication optimization.

Background: Improved health outcomes and lower costs have been reported with pharmacist-led patient-centered approaches to medication optimization in older adults, but heterogeneity in studies has complicated assessments of how well these approaches have worked. Among the challenges in advancing care from patient-centered research is uncertainty in how well research questions have matched patients' care needs. One strategy is to engage patients, ideally as equal partners, in the preparation, execution, and dissemination of research.

Applying the Andersen behavioral model to the medication therapy management program: an approach for improving medication safety in older adults.

Medication therapy problems (MTPs) are common among older adults and are associated with considerable morbidity, mortality, and healthcare costs. The Medicare Part D Medication Therapy Management (MTM) program, which includes Comprehensive Medication Reviews (CMRs), Targeted Medication Reviews (TMRs), and guidance on safe medication disposal, is designed to optimize therapeutic outcomes and reduce adverse events by addressing MTPs. Although this program has demonstrated success in reducing MTPs, its utilization remains low, with ongoing concerns about service access disparities, patient satisfaction, and long-term health outcomes.

A Nursing Home Clinician Survey to Explain Gabapentinoid Increases.

Objectives: Survey nursing home (NH) clinicians about the indications for NH gabapentinoid use, the factors driving increased prescribing, and their experiences with gabapentinoid deprescribing.

Design: Online clinician survey.

Setting And Participants: NH clinicians prescribing gabapentinoids in US NHs.