Publications by authors named "N Brambilla"
Application of Robotic-Assisted Percutaneous Coronary Intervention for Acute Coronary Syndrome: A Case Series.
Catheter Cardiovasc Interv
December 2024
This case series highlights the successful application of robotic-assisted percutaneous coronary intervention using the R-One+ system in two acute coronary syndrome patients with significant coronary lesions. The procedures demonstrated the technology's safety, performance, and benefits such as minimal contrast use, reduced operator radiation exposure, and optimal procedural times.
View Article and Find Full Text PDFPurpose: Novel combinations are required to overcome resistance to immune checkpoint inhibitors (ICIs) in proficient mismatch repair (pMMR) or microsatellite stable (MSS) metastatic colorectal cancer (mCRC). We aimed to determine whether vorbipiprant, a prostaglandin EP4 receptor antagonist, can convert immune-resistant mCRC into a tumor responsive to anti-PD-1 inhibition.
Patients And Methods: This phase 1b/2a prospective, open-label, single-arm trial followed a 3 + 3 dose escalation and dose optimization design.
Article Synopsis
- The study examines the characteristics and outcomes of patients with tapered raphe-type bicuspid aortic valve (BAV) when undergoing trans-catheter aortic valve replacement (TAVR), focusing on the safety and effectiveness of modern heart valves.
- Researchers analyzed data from 897 patients, finding that those with tapered configurations showed similar success rates and safety between two sizing strategies: annular and supra-annular.
- The results indicate that TAVR is a safe and effective procedure for these patients, regardless of the sizing method used, maintaining a high rate of clinical efficacy at mid-term follow-up.
Article Synopsis
- This study explores how the curvature and angulation of the aortic landing zone (LZ) can influence the depth of transcatheter aortic valve implantation (TAVI) using different types of devices: balloon-expanding (BE) and self-expanding (SE) valves.* -
- Researchers found that SE devices exhibited greater LZ curvature and angulation characteristics compared to BE devices, affecting how deep the valves were implanted in patients.* -
- The study concluded that greater LZ curvature (specifically at angles above 17.8°) was a reliable predictor of deeper implantation for SE devices, suggesting that device selection and anatomical factors need to be carefully considered during TAVI procedures.*
Background: Mitral transcatheter edge-to-edge repair (M-TEER) is a guideline-recommended treatment option for patients with severe symptomatic mitral regurgitation (MR). Outcomes with the PASCAL system in a post-market setting have not been established.
Objectives: The authors report 30-day and 1-year outcomes from the MiCLASP (Transcatheter Repair of Mitral Regurgitation with Edwards PASCAL Transcatheter Valve Repair System) European post-market clinical follow-up study.