Publications by authors named "N Boujelbene"
Background: Gastric cancer (GC) remains a serious health concern and is characterized by a multifactorial etiology involving both genetic and epigenetic factors. The aim of the current study was to examine the relationship between Human leukocyte antigen (HLA)-G 3'UTR polymorphisms and the expression of HLA-G in both tumor tissues and plasma samples from patients with GC in the Tunisian population.
Methods: HLA-G 3'UTR polymorphisms (14pb Insertion/deletion and + 3142C/G) were identified by polymerase chain reaction (PCR) or Sanger sequencing.
Article Synopsis
- HLA-G 14-bp insertion/deletion polymorphism is linked to cancer risk, particularly associated with the D allele, suggesting it may contribute to cancer cell escape mechanisms.
- A meta-analysis of 39 studies showed a significant association between this polymorphism and breast cancer, with specific variations in risk based on ethnicity and geographic location.
- Significant cancer risks linked to the D allele were observed in populations from North Africa, the Middle East, and South America, but no such risks were noted in Europe or North Asia.
Introduction And Importance: Desmoid-type fibromatosis is an uncommon tumor characterized by its local invasiveness, with shoulder involvement being notably infrequent. The optimal treatment strategy for this tumor remains a topic of ongoing debate.
Case Presentation: A 47-year-old Tunisian woman with a history of hypothyroidism, presented with pain and swelling in her left shoulder for a year.
Introduction: Intravenous leiomyomatosis (IVL), a rare type of uterine leiomyoma (its incidence is about 0.25% to 0.40% of patients who present uterine fibroma), is characterized by the formation and growth of benign leiomyoma tissue within the vascular wall or lymphatic lumen.
View Article and Find Full Text PDFIntroduction And Importance: Neoplasms with perivascular epithelioid-cell differentiation (PEComa) are rare. We present a case of multifocal malignant PEComas arising in the peritoneum.
Case Presentation: A 61-year-old woman presented with a painful abdominal mass that had progressed over the past year and recently increased in size.