[Combined ROLL and sentinel lymph node: a new strategy in radio-guided surgery].

Radioguided surgery for the treatment of breast cancer is becoming the gold standard for both diagnosis and therapy. The main rule in using ROLL is perfect localization of non-palpable lesions and minimal invasiveness of excision. The same criteria apply to the sentinel lymph node technique.

Retrospective analysis of the association of nodular goiter with primary and secondary hyperparathyroidism.

Background: The association of hyperparathyroidism (HPT) with thyroid disease has long been known, but the mechanisms underlying such an association have not yet been clarified.

Objective: To elucidate the main factors determining this combination of endocrine diseases, in a retrospective multicenter study.

Methods: We retrospectively reviewed all patients referred for parathyroid scintigraphy in the period 1990-1999.

[Non-secretory myeloma syndrome].

Non secretory myeloma is a rare and unusual form of myeloma, characterized by the absence of monoclonal component in serum and urine. This peculiarity is usually believed to be caused by the incapacity of neoplastic plasmacells to synthesize or secrete M-component, but it is probably due to several pathogenetic mechanisms which are different from case to case. The diagnosis can be delayed by the non specific clinical pattern, especially in those cases where skeletal radiological studies do not reveal lytic lesions.

Localization of parathyroid tumours in the minimally invasive era: which technique should be chosen? Population-based analysis of 253 patients undergoing parathyroidectomy and factors affecting parathyroid gland detection.

A series of 253 consecutive patients with proved primary hyperparathyroidism due to parathyroid tumours was reviewed. There were 68 (26.9%) men and 185 (73.

Parathyroid imaging with pertechnetate plus perchlorate/MIBI subtraction scintigraphy: a fast and effective technique.

We set up a modified technetium-99m (Tc-99m) pertechnetate/Tc-99m MIBI (Tc-MIBI) subtraction scintigraphy for parathyroid imaging by introducing the use of potassium perchlorate (KCLO4). Initially, the effect of KCLO4 on technetium thyroid wash-out was evaluated in five healthy volunteers: 40-minute dynamic studies of the thyroid were obtained 20 minutes after the injection of technetium 150 MBq (4 mCi), both in baseline conditions and after the oral administration of 400 mg KCLO4. After an average latency time of 10.